11 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 01/07/1921 | A | Cincinnati | L | 16 | 36 | 0-1 | |||||||||
| 01/08/1921 | A | Cincinnati Gym | L | 12 | 29 | 0-2 | |||||||||
| 01/15/1921 | H | Centre | L | 20 | 34 | 0-3 | Louisville | Ky. | YMCA Gymnasium | ||||||
| 01/22/1921 | H | Chattanooga | L | 28 | 33 | 0-4 | Louisville | Ky. | St. Xavier Gymnasium | ||||||
| 02/01/1921 | H | Butler | L | 24 | 62 | 0-5 | New Albany | Ind. | Calumet Club | ||||||
| 02/04/1921 | A | Indiana | L | 17 | 34 | 0-6 | Bloomington | Ind. | |||||||
| 02/08/1921 | A | Transylvania | L | 15 | 29 | 0-7 | |||||||||
| 02/11/1921 | H | Cumberland | W | 35 | 20 | 1-7 | Louisville | Ky. | YMCA Gymnasium | ||||||
| 02/18/1921 | H | Georgetown College | W | 30 | 29 | 2-7 | Louisville | Ky. | |||||||
| 02/26/1921 | H | Transylvania | W | 24 | 20 | 3-7 | Louisville | Ky. | St. Xavier Gymnasium | ||||||
| 03/01/1921 | A | Louisville YMHA | L | 30 | 41 | 3-8 | Louisville | Ky. | YMHA Gymnasium |