14 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 01/14/1922 | H | Franklin | L | 13 | 28 | 0-1 | Louisville | Ky. | |||||||
| 01/17/1922 | H | Kentucky | L | 14 | 38 | 0-2 | Louisville | Ky. | St. Xavier Gymnasium | ||||||
| 01/20/1922 | A | Georgetown College | L | 12 | 26 | 0-3 | |||||||||
| 01/21/1922 | A | Kentucky | L | 22 | 29 | 0-4 | Lexington | Ky. | |||||||
| 01/27/1922 | A | Cumberland | L | 19 | 30 | 0-5 | |||||||||
| 01/28/1922 | A | Chattanooga | L | 8 | 34 | 0-6 | |||||||||
| 02/03/1922 | H | Georgetown College | L | 14 | 18 | 0-7 | Louisville | Ky. | St. Xavier Gymnasium | ||||||
| 02/11/1922 | H | Cumberland | L | 13 | 19 | 0-8 | Louisville | Ky. | St. Xavier Gymnasium | ||||||
| 02/14/1922 | A | Centre | L | 12 | 25 | 0-9 | |||||||||
| 02/16/1922 | A | Tennessee | L | 22 | 28 | 0-10 | |||||||||
| 02/18/1922 | H | Transylvania | W | 23 | 12 | 1-10 | Louisville | Ky. | YMCA Gymnasium | ||||||
| 02/25/1922 | A | Louisville YMHA | L | 15 | 27 | 1-11 | Louisville | Ky. | YMHA Gymnasium | ||||||
| 03/01/1922 | H | Rose Poly | L | 19 | 38 | 1-12 | Louisville | Ky. | St. Xavier Gymnasium | ||||||
| 03/04/1922 | H | Centre | L | 18 | 27 | OT | 1-13 | Louisville | Ky. | YMCA Gymnasium |