32 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 11/24/1978 | N | Penn State | 4 | W | 89 | 58 | 1-0 | 0-0 | 2,500 | Anchorage | Alaska | Buckner Fieldhouse | 1978 Seawolf Classic | ||
| 11/25/1978 | N | Lamar | 4 | W | 90 | 68 | 2-0 | 0-0 | 3,000 | Anchorage | Alaska | Buckner Fieldhouse | 1978 Seawolf Classic | ||
| 11/26/1978 | N | 12 | North Carolina State | 4 | L | 66 | 72 | 2-1 | 0-0 | 3,600 | Anchorage | Alaska | Buckner Fieldhouse | 1978 Seawolf Classic | |
| 12/02/1978 | H | Tennessee | 5 | W | 82 | 61 | 3-1 | 0-0 | 16,613 | Louisville | Ky. | Freedom Hall | |||
| 12/06/1978 | H | 6 | Michigan | 7 | W | 86 | 84 | 4-1 | 0-0 | 16,613 | Louisville | Ky. | Freedom Hall | ||
| 12/09/1978 | H | Idaho | 7 | W | 101 | 54 | 5-1 | 0-0 | 14,038 | Louisville | Ky. | Freedom Hall | |||
| 12/12/1978 | A | Ohio State | 4 | L | 69 | 85 | 5-2 | 0-0 | 13,327 | Columbus | Ohio | St. John Arena | |||
| 12/16/1978 | H | West Virginia | 4 | W | 106 | 60 | 6-2 | 0-0 | 15,338 | Louisville | Ky. | Freedom Hall | |||
| 12/23/1978 | H | Providence | 12 | W | 88 | 70 | 7-2 | 0-0 | 16,075 | Louisville | Ky. | Freedom Hall | |||
| 12/28/1978 | H | Wisconsin | 10 | W | 70 | 53 | 8-2 | 0-0 | 12,961 | Louisville | Ky. | Freedom Hall | 1978 Louisville Holiday Classic | ||
| 12/29/1978 | H | Mississippi State | 10 | L | 73 | 80 | 8-3 | 0-0 | 12,504 | Louisville | Ky. | Freedom Hall | 1978 Louisville Holiday Classic | ||
| 01/04/1979 | H | Chattanooga | 16 | W | 94 | 70 | 9-3 | 0-0 | 12,467 | Louisville | Ky. | Freedom Hall | |||
| 01/06/1979 | H | Louisiana-Lafayette | 16 | W | 73 | 60 | 10-3 | 0-0 | 10,547 | Louisville | Ky. | Freedom Hall | |||
| 01/08/1979 | H | Marshall | 12 | W | 112 | 64 | 11-3 | 0-0 | 8,783 | Louisville | Ky. | Freedom Hall | |||
| 01/13/1979 | A | Maryland | 12 | W | 99 | 84 | 12-3 | 0-0 | 14,500 | College Park | Md. | Cole Fieldhouse | |||
| 01/16/1979 | A | Dayton | 7 | W | 77 | 76 | 13-3 | 0-0 | 13,458 | Dayton | Ohio | University of Dayton Arena | |||
| 01/18/1979 | A | Cincinnati | 7 | W | 82 | 77 | 14-3 | 1-0 | 11,440 | Cincinnati | Ohio | Riverfront Coliseum | |||
| 01/20/1979 | A | Florida State | 7 | W | 67 | 65 | 15-3 | 2-0 | 3,119 | Tallahassee | Fla. | Tully Gymnasium | |||
| 01/24/1979 | H | Saint Louis | 5 | W | 80 | 65 | 16-3 | 3-0 | 13,911 | Louisville | Ky. | Freedom Hall | |||
| 01/28/1979 | H | Virginia Tech | 5 | W | 82 | 72 | 17-3 | 3-0 | 12,667 | Louisville | Ky. | Freedom Hall | |||
| 01/31/1979 | H | Florida State | 6 | W | 84 | 71 | 18-3 | 4-0 | 16,433 | Louisville | Ky. | Freedom Hall | |||
| 02/03/1979 | H | Cincinnati | 6 | W | 88 | 85 | 19-3 | 5-0 | 16,613 | Louisville | Ky. | Freedom Hall | |||
| 02/05/1979 | H | Memphis | 5 | W | 103 | 82 | 20-3 | 6-0 | 16,452 | Louisville | Ky. | Freedom Hall | |||
| 02/08/1979 | A | Tulane | 5 | W | 77 | 66 | 21-3 | 7-0 | 2,578 | New Orleans | La. | Superdome | |||
| 02/10/1979 | A | 9 | Marquette | 5 | L | 55 | 71 | 21-4 | 7-0 | 10,938 | Milwaukee | Wisc. | Milwaukee Civic Center Arena | ||
| 02/15/1979 | A | Saint Louis | 9 | W | 78 | 62 | 22-4 | 8-0 | 5,579 | St. Louis | Mo. | Checkerdome Arena | |||
| 02/17/1979 | A | Memphis | 9 | L | 53 | 60 | 22-5 | 8-1 | 10,165 | Memphis | Tenn. | Mid-South Coliseum | |||
| 02/18/1979 | N | 5 | Duke | 9 | L | 72 | 88 | 22-6 | 8-1 | 3,866 | Charlotte | N.C. | Charlotte Coliseum | ||
| 02/24/1979 | H | Tulane | 13 | W | 95 | 71 | 23-6 | 9-1 | 11,853 | Louisville | Ky. | Freedom Hall | |||
| 03/02/1979 | N | Virginia Tech | 13 | L | 68 | 72 | 23-7 | 9-1 | 9,167 | Memphis | Tenn. | Mid-South Coliseum | 1979 Metro Tournament Semifinal | ||
| 03/10/1979 | N | South Alabama | 18 | W | 69 | 66 | 24-7 | 9-1 | 9,681 | Dallas | Texas | Moody Coliseum | 1979 NCAA Tournament Midwest Regional Second Round | ||
| 03/15/1979 | N | 5 | Arkansas | 13 | L | 62 | 73 | 24-8 | 9-1 | 17,252 | Cincinnati | Ohio | Riverfront Coliseum | 1979 NCAA Tournament Midwest Regional Semifinal |