37 games, 2 exhibitions
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 11/01/2008 | H | Georgetown College (Exhibition) | 3 | W | 74 | 67 | 17,521 | Louisville | Ky. | Freedom Hall | |||||
| 11/08/2008 | A | Northern Kentucky (Exhibition) | 3 | W | 84 | 69 | 8,408 | Highland Heights | Ky. | Bank of Kentucky Center | |||||
| 11/22/2008 | H | Morehead State | 3 | W | 79 | 41 | 1-0 | 0-0 | 19,493 | Louisville | Ky. | Freedom Hall | 2008 Billy Minardi Classic | ||
| 11/23/2008 | H | South Alabama | 3 | W | 81 | 54 | 2-0 | 0-0 | 19,241 | Louisville | Ky. | Freedom Hall | 2008 Billy Minardi Classic | ||
| 11/30/2008 | N | Western Kentucky | 3 | L | 54 | 68 | 2-1 | 0-0 | 8,193 | Nashville | Tenn. | Sommet Center | |||
| 12/06/2008 | H | Indiana State | 11 | W | 83 | 43 | 3-1 | 0-0 | 18,924 | Louisville | Ky. | Freedom Hall | 2008 Marques Maybin Classic | ||
| 12/07/2008 | H | Ohio | 11 | W | 91 | 56 | 4-1 | 0-0 | 19,083 | Louisville | Ky. | Freedom Hall | 2008 Marques Maybin Classic | ||
| 12/08/2008 | H | Lamar | 9 | W | 78 | 56 | 5-1 | 0-0 | 19,058 | Louisville | Ky. | Freedom Hall | 2008 Marques Maybin Classic | ||
| 12/13/2008 | H | Austin Peay | 9 | W | 94 | 75 | 6-1 | 0-0 | 19,288 | Louisville | Ky. | Freedom Hall | |||
| 12/18/2008 | N | Mississippi | 9 | W | 77 | 68 | 7-1 | 0-0 | 5,922 | Cincinnati | Ohio | U.S. Bank Arena | 2008 SEC Big East Challenge | ||
| 12/20/2008 | N | Minnesota | 9 | L | 64 | 70 | 7-2 | 0-0 | 10,431 | Glendale | Ariz. | University of Phoenix Stadium | 2008 Stadium Shootout | ||
| 12/27/2008 | H | Alabama-Birmingham | 19 | W | 82 | 62 | 8-2 | 0-0 | 19,627 | Louisville | Ky. | Freedom Hall | |||
| 12/31/2008 | H | Nevada-Las Vegas | 18 | L | 55 | 56 | 8-3 | 0-0 | 19,314 | Louisville | Ky. | Freedom Hall | |||
| 01/04/2009 | H | Kentucky | 18 | W | 74 | 71 | 9-3 | 0-0 | 20,078 | Louisville | Ky. | Freedom Hall | |||
| 01/07/2009 | A | South Florida | 23 | W | 71 | 57 | 10-3 | 1-0 | 4,827 | Tampa | Fla. | USF Sun Dome | |||
| 01/10/2009 | A | 18 | Villanova | 23 | W | 61 | 60 | 11-3 | 2-0 | 17,117 | Philadelphia | Pa. | Wachovia Center | ||
| 01/12/2009 | H | 12 | Notre Dame | 20 | W | 87 | 73 | OT | 12-3 | 3-0 | 19,865 | Louisville | Ky. | Freedom Hall | |
| 01/17/2009 | H | 1 | Pittsburgh | 20 | W | 69 | 63 | 13-3 | 4-0 | 20,082 | Louisville | Ky. | Freedom Hall | ||
| 01/21/2009 | A | Rutgers | 9 | W | 78 | 59 | 14-3 | 5-0 | 5,178 | Piscataway | N.J. | Louis Brown Athletic Center | |||
| 01/25/2009 | A | 8 | Syracuse | 9 | W | 67 | 57 | 15-3 | 6-0 | 25,721 | Syracuse | N.Y. | Carrier Dome | ||
| 01/28/2009 | H | South Florida | 7 | W | 80 | 54 | 16-3 | 7-0 | 17,184 | Louisville | Ky. | Freedom Hall | |||
| 01/31/2009 | H | West Virginia | 7 | W | 69 | 63 | 17-3 | 8-0 | 19,416 | Louisville | Ky. | Freedom Hall | |||
| 02/02/2009 | H | 1 | Connecticut | 5 | L | 51 | 68 | 17-4 | 8-1 | 20,069 | Louisville | Ky. | Freedom Hall | ||
| 02/08/2009 | A | St. John's | 5 | W | 60 | 47 | 18-4 | 9-1 | 6,128 | New York | N.Y. | Madison Square Garden IV | |||
| 02/12/2009 | A | Notre Dame | 5 | L | 57 | 90 | 18-5 | 9-2 | 11,418 | South Bend | Ind. | Joyce Athletic and Convocation Center | |||
| 02/15/2009 | H | DePaul | 5 | W | 99 | 54 | 19-5 | 10-2 | 19,322 | Louisville | Ky. | Freedom Hall | |||
| 02/18/2009 | H | Providence | 7 | W | 94 | 76 | 20-5 | 11-2 | 19,484 | Louisville | Ky. | Freedom Hall | |||
| 02/21/2009 | A | Cincinnati | 7 | W | 72 | 63 | 21-5 | 12-2 | 12,350 | Cincinnati | Ohio | Fifth Third Arena | |||
| 02/23/2009 | A | Georgetown | 6 | W | 76 | 58 | 22-5 | 13-2 | 12,653 | Washington | D.C. | Verizon Center | |||
| 03/01/2009 | H | 8 | Marquette | 6 | W | 62 | 58 | 23-5 | 14-2 | 20,079 | Louisville | Ky. | Freedom Hall | ||
| 03/04/2009 | H | Seton Hall | 6 | W | 95 | 78 | 24-5 | 15-2 | 19,535 | Louisville | Ky. | Freedom Hall | |||
| 03/07/2009 | A | West Virginia | 6 | W | 62 | 59 | 25-5 | 16-2 | 13,089 | Morgantown | W.V. | WVU Coliseum | |||
| 03/12/2009 | N | Providence | 5 | W | 73 | 55 | 26-5 | 16-2 | 19,375 | New York | N.Y. | Madison Square Garden IV | 2009 Big East Tournament Quarterfinal | ||
| 03/13/2009 | N | 10 | Villanova | 5 | W | 69 | 55 | 27-5 | 16-2 | 19,375 | New York | N.Y. | Madison Square Garden IV | 2009 Big East Tournament Semifinal | |
| 03/14/2009 | N | 18 | Syracuse | 5 | W | 76 | 66 | 28-5 | 16-2 | 19,375 | New York | N.Y. | Madison Square Garden IV | 2009 Big East Tournament Final | |
| 03/20/2009 | N | Morehead State | 1 | W | 74 | 54 | 29-5 | 16-2 | 12,499 | Dayton | Ohio | University of Dayton Arena | 2009 NCAA Tournament Midwest Regional First Round | ||
| 03/22/2009 | N | Siena | 1 | W | 79 | 72 | 30-5 | 16-2 | 12,596 | Dayton | Ohio | University of Dayton Arena | 2009 NCAA Tournament Midwest Regional Second Round | ||
| 03/27/2009 | N | Arizona | 1 | W | 103 | 64 | 31-5 | 16-2 | 33,780 | Indianapolis | Ind. | Lucas Oil Stadium | 2009 NCAA Tournament Midwest Regional Semifinal | ||
| 03/29/2009 | N | 8 | Michigan State | 1 | L | 52 | 64 | 31-6 | 16-2 | 36,084 | Indianapolis | Ind. | Lucas Oil Stadium | 2009 NCAA Tournament Midwest Regional Final |