33 games, 2 exhibitions
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 10/28/2009 | H | Georgetown College (Exhibition) | W | 80 | 68 | 17,184 | Louisville | Ky. | Freedom Hall | ||||||
| 11/04/2009 | H | Bellarmine (Exhibition) | 19 | W | 88 | 65 | 18,304 | Louisville | Ky. | Freedom Hall | |||||
| 11/17/2009 | N | Arkansas | 20 | W | 96 | 66 | 1-0 | 0-0 | 12,017 | St. Louis | Mo. | Scottrade Center | 2009 Hall of Fame Showcase | ||
| 11/21/2009 | H | East Tennessee State | 20 | W | 69 | 56 | 2-0 | 0-0 | 19,179 | Louisville | Ky. | Freedom Hall | 2009 Hall of Fame Showcase | ||
| 11/22/2009 | H | Morgan State | 20 | W | 90 | 81 | 3-0 | 0-0 | 18,942 | Louisville | Ky. | Freedom Hall | 2009 Hall of Fame Showcase | ||
| 11/23/2009 | H | Appalachian State | 16 | W | 80 | 53 | 4-0 | 0-0 | 19,027 | Louisville | Ky. | Freedom Hall | 2009 Hall of Fame Showcase | ||
| 11/28/2009 | A | Nevada-Las Vegas | 16 | L | 71 | 76 | 4-1 | 0-0 | 14,390 | Las Vegas | Nev. | Thomas & Mack Center | |||
| 12/02/2009 | H | Stetson | 20 | W | 80 | 48 | 5-1 | 0-0 | 18,916 | Louisville | Ky. | Freedom Hall | |||
| 12/05/2009 | H | Charlotte | 20 | L | 65 | 87 | 5-2 | 0-0 | 19,221 | Louisville | Ky. | Freedom Hall | |||
| 12/12/2009 | H | Western Carolina | L | 83 | 91 | 5-3 | 0-0 | 19,247 | Louisville | Ky. | Freedom Hall | ||||
| 12/16/2009 | H | Oral Roberts | W | 94 | 57 | 6-3 | 0-0 | 18,868 | Louisville | Ky. | Freedom Hall | ||||
| 12/19/2009 | H | Western Kentucky | W | 102 | 75 | 7-3 | 0-0 | 19,531 | Louisville | Ky. | Freedom Hall | 2009 Billy Minardi Classic | |||
| 12/23/2009 | H | Louisiana-Lafayette | W | 84 | 69 | 8-3 | 0-0 | 18,894 | Louisville | Ky. | Freedom Hall | ||||
| 12/27/2009 | H | Radford | W | 79 | 53 | 9-3 | 0-0 | 19,265 | Louisville | Ky. | Freedom Hall | ||||
| 12/30/2009 | H | South Florida | W | 73 | 52 | 10-3 | 1-0 | 19,386 | Louisville | Ky. | Freedom Hall | ||||
| 01/02/2010 | A | 3 | Kentucky | L | 62 | 71 | 10-4 | 1-0 | 24,479 | Lexington | Ky. | Rupp Arena | |||
| 01/06/2010 | A | Providence | W | 92 | 70 | 11-4 | 2-0 | 9,207 | Providence | R.I. | Dunkin' Donuts Center | ||||
| 01/09/2010 | H | St. John's | W | 75 | 68 | 12-4 | 3-0 | 19,263 | Louisville | Ky. | Freedom Hall | ||||
| 01/11/2010 | H | 4 | Villanova | L | 84 | 92 | 12-5 | 3-1 | 20,076 | Louisville | Ky. | Freedom Hall | |||
| 01/16/2010 | A | 16 | Pittsburgh | L | 77 | 82 | OT | 12-6 | 3-2 | 12,781 | Pittsburgh | Pa. | Petersen Events Center | ||
| 01/21/2010 | A | Seton Hall | L | 77 | 80 | 12-7 | 3-3 | 7,139 | Newark | N.J. | Prudential Center | ||||
| 01/24/2010 | H | Cincinnati | W | 68 | 60 | 13-7 | 4-3 | 19,617 | Louisville | Ky. | Freedom Hall | ||||
| 01/30/2010 | A | 9 | West Virginia | L | 74 | 77 | 13-8 | 4-4 | 12,471 | Morgantown | W.V. | WVU Coliseum | |||
| 02/01/2010 | H | Connecticut | W | 82 | 69 | 14-8 | 5-4 | 19,655 | Louisville | Ky. | Freedom Hall | ||||
| 02/06/2010 | H | Rutgers | W | 76 | 60 | 15-8 | 6-4 | 19,775 | Louisville | Ky. | Freedom Hall | ||||
| 02/11/2010 | A | St. John's | L | 55 | 74 | 15-9 | 6-5 | 5,748 | New York | N.Y. | Madison Square Garden IV | ||||
| 02/14/2010 | A | 2 | Syracuse | W | 66 | 60 | 16-9 | 7-5 | 31,053 | Syracuse | N.Y. | Carrier Dome | |||
| 02/17/2010 | H | Notre Dame | W | 91 | 89 | 2OT | 17-9 | 8-5 | 19,623 | Louisville | Ky. | Freedom Hall | |||
| 02/20/2010 | A | DePaul | W | 68 | 59 | 18-9 | 9-5 | 13,754 | Rosemont | Ill. | Allstate Arena | ||||
| 02/23/2010 | H | 11 | Georgetown | L | 60 | 70 | 18-10 | 9-6 | 19,917 | Louisville | Ky. | Freedom Hall | |||
| 02/28/2010 | A | Connecticut | W | 78 | 76 | 19-10 | 10-6 | 10,167 | Storrs | Conn. | Harry A. Gampel Pavilion | ||||
| 03/02/2010 | A | Marquette | L | 48 | 69 | 19-11 | 10-7 | 16,281 | Milwaukee | Wisc. | Bradley Center | ||||
| 03/06/2010 | H | 1 | Syracuse | W | 78 | 68 | 20-11 | 11-7 | 20,135 | Louisville | Ky. | Freedom Hall | |||
| 03/10/2010 | N | Cincinnati | L | 66 | 69 | 20-12 | 11-7 | 19,375 | New York | N.Y. | Madison Square Garden IV | 2010 Big East Tournament Second Round | |||
| 03/19/2010 | N | California | L | 62 | 77 | 20-13 | 11-7 | 12,251 | Jacksonville | Fla. | Jacksonville Veterans Memoria Arena | 2010 NCAA Tournament South Regional First Round |