40 games, 4 exhibitions
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 08/11/2011 | A | Commonwealth (Exhibition) | W | 115 | 54 | Nassau | Bahamas | Sir Kendal Isaac Gymnasium | |||||||
| 08/12/2011 | A | Real Deal (Exhibition) | W | 113 | 58 | Nassau | Bahamas | Sir Kendal Isaac Gymnasium | |||||||
| 10/26/2011 | H | Pikeville (Exhibition) | W | 74 | 55 | 18,866 | Louisville | Ky. | KFC Yum! Center | ||||||
| 11/03/2011 | H | Bellarmine (Exhibition) | 9 | W | 62 | 54 | 20,389 | Louisville | Ky. | KFC Yum! Center | |||||
| 11/11/2011 | H | Tennessee-Martin | 9 | W | 83 | 48 | 1-0 | 0-0 | 20,485 | Louisville | Ky. | KFC Yum! Center | 2011 Global Sports Invitational | ||
| 11/13/2011 | H | Lamar | 9 | W | 68 | 48 | 2-0 | 0-0 | 19,842 | Louisville | Ky. | KFC Yum! Center | 2011 Global Sports Invitational | ||
| 11/19/2011 | A | Butler | 8 | W | 69 | 53 | 3-0 | 0-0 | 9,071 | Indianapolis | Ind. | Hinkle Fieldhouse | |||
| 11/22/2011 | H | Arkansas State | 7 | W | 54 | 27 | 4-0 | 0-0 | 20,323 | Louisville | Ky. | KFC Yum! Center | 2011 Global Sports Invitational | ||
| 11/25/2011 | H | Ohio | 7 | W | 59 | 54 | 5-0 | 0-0 | 21,334 | Louisville | Ky. | KFC Yum! Center | 2011 Global Sports Invitational | ||
| 11/28/2011 | H | Long Beach State | 6 | W | 79 | 66 | 6-0 | 0-0 | 20,468 | Louisville | Ky. | KFC Yum! Center | |||
| 12/02/2011 | H | 20 | Vanderbilt | 6 | W | 62 | 60 | OT | 7-0 | 0-0 | 22,728 | Louisville | Ky. | KFC Yum! Center | 2011 SEC Big East Challenge |
| 12/07/2011 | H | IUPUI | 5 | W | 90 | 60 | 8-0 | 0-0 | 20,604 | Louisville | Ky. | KFC Yum! Center | |||
| 12/10/2011 | H | Fairleigh Dickinson | 5 | W | 80 | 58 | 9-0 | 0-0 | 20,287 | Louisville | Ky. | KFC Yum! Center | |||
| 12/17/2011 | H | Memphis | 4 | W | 95 | 87 | 10-0 | 0-0 | 22,733 | Louisville | Ky. | KFC Yum! Center | 2011 Basketball Hall of Fame Shootout | ||
| 12/20/2011 | H | College of Charleston | 4 | W | 69 | 62 | 11-0 | 0-0 | 20,752 | Louisville | Ky. | KFC Yum! Center | |||
| 12/23/2011 | H | Western Kentucky | 4 | W | 70 | 60 | 12-0 | 0-0 | 22,150 | Louisville | Ky. | KFC Yum! Center | 2011 Billy Minardi Classic | ||
| 12/28/2011 | H | 12 | Georgetown | 4 | L | 68 | 71 | 12-1 | 0-1 | 22,517 | Louisville | Ky. | KFC Yum! Center | ||
| 12/31/2011 | A | 3 | Kentucky | 4 | L | 62 | 69 | 12-2 | 0-1 | 24,387 | Lexington | Ky. | Rupp Arena | ||
| 01/03/2012 | A | St. John's | 11 | W | 73 | 58 | 13-2 | 1-1 | 9,258 | New York | N.Y. | Madison Square Garden IV | |||
| 01/07/2012 | H | Notre Dame | 11 | L | 65 | 67 | 2OT | 13-3 | 1-2 | 22,687 | Louisville | Ky. | KFC Yum! Center | ||
| 01/10/2012 | A | Providence | 14 | L | 59 | 90 | 13-4 | 1-3 | 8,163 | Providence | R.I. | Dunkin' Donuts Center | |||
| 01/14/2012 | H | DePaul | 14 | W | 76 | 59 | 14-4 | 2-3 | 21,223 | Louisville | Ky. | KFC Yum! Center | |||
| 01/16/2012 | A | 21 | Marquette | 23 | L | 63 | 74 | 14-5 | 2-4 | 16,688 | Milwaukee | Wisc. | Bradley Center | ||
| 01/21/2012 | A | Pittsburgh | 23 | W | 73 | 62 | 15-5 | 3-4 | 12,508 | Pittsburgh | Pa. | Petersen Events Center | |||
| 01/25/2012 | H | Villanova | W | 84 | 74 | 16-5 | 4-4 | 21,219 | Louisville | Ky. | KFC Yum! Center | ||||
| 01/28/2012 | A | Seton Hall | W | 60 | 51 | 17-5 | 5-4 | 9,573 | Newark | N.J. | Prudential Center | ||||
| 02/04/2012 | H | Rutgers | W | 78 | 66 | 18-5 | 6-4 | 21,298 | Louisville | Ky. | KFC Yum! Center | ||||
| 02/06/2012 | H | Connecticut | 24 | W | 80 | 59 | 19-5 | 7-4 | 21,804 | Louisville | Ky. | KFC Yum! Center | |||
| 02/11/2012 | A | West Virginia | 24 | W | 77 | 74 | 20-5 | 8-4 | 11,254 | Morgantown | W.V. | WVU Coliseum | |||
| 02/13/2012 | H | 2 | Syracuse | 19 | L | 51 | 52 | 20-6 | 8-5 | 22,738 | Louisville | Ky. | KFC Yum! Center | ||
| 02/18/2012 | A | DePaul | 19 | W | 90 | 82 | OT | 21-6 | 9-5 | 13,674 | Rosemont | Ill. | Allstate Arena | ||
| 02/23/2012 | A | Cincinnati | 17 | L | 56 | 60 | 21-7 | 9-6 | 13,176 | Cincinnati | Ohio | Fifth Third Arena | |||
| 02/26/2012 | H | Pittsburgh | 17 | W | 57 | 54 | 22-7 | 10-6 | 22,746 | Louisville | Ky. | KFC Yum! Center | |||
| 02/29/2012 | H | South Florida | 19 | L | 51 | 58 | 22-8 | 10-7 | 22,114 | Louisville | Ky. | KFC Yum! Center | |||
| 03/03/2012 | A | 2 | Syracuse | 19 | L | 49 | 58 | 22-9 | 10-8 | 33,205 | Syracuse | N.Y. | Carrier Dome | ||
| 03/07/2012 | N | Seton Hall | W | 61 | 55 | 23-9 | 10-8 | 20,057 | New York | N.Y. | Madison Square Garden IV | 2012 Big East Tournament Second Round | |||
| 03/08/2012 | N | 9 | Marquette | W | 84 | 71 | 24-9 | 10-8 | 20,057 | New York | N.Y. | Madison Square Garden IV | 2012 Big East Tournament Quarterfinal | ||
| 03/09/2012 | N | 23 | Notre Dame | W | 64 | 50 | 25-9 | 10-8 | 20,057 | New York | N.Y. | Madison Square Garden IV | 2012 Big East Tournament Semifinal | ||
| 03/10/2012 | N | Cincinnati | W | 50 | 44 | 26-9 | 10-8 | 20,057 | New York | N.Y. | Madison Square Garden IV | 2012 Big East Tournament Final | |||
| 03/15/2012 | N | Davidson | 17 | W | 69 | 62 | 27-9 | 10-8 | 17,050 | Portland | Ore. | Rose Garden | 2012 NCAA Tournament West Regional Second Round | ||
| 03/17/2012 | N | 21 | New Mexico | 17 | W | 59 | 56 | 28-9 | 10-8 | 18,167 | Portland | Ore. | Rose Garden | 2012 NCAA Tournament West Regional Third Round | |
| 03/22/2012 | N | 5 | Michigan State | 17 | W | 57 | 44 | 29-9 | 10-8 | 14,913 | Phoenix | Ariz. | US Airways Center | 2012 NCAA Tournament West Regional Semifinal | |
| 03/24/2012 | N | 25 | Florida | 17 | W | 72 | 68 | 30-9 | 10-8 | 13,456 | Phoenix | Ariz. | US Airways Center | 2012 NCAA Tournament West Regional Final | |
| 03/31/2012 | N | 1 | Kentucky | 17 | L | 61 | 69 | 30-10 | 10-8 | 73,361 | New Orleans | La. | Mercedes-Benz Superdome | 2012 NCAA Tournament Semifinal |