40 games, 2 exhibitions
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 11/01/2012 | H | Pikeville (Exhibition) | 2 | W | 93 | 57 | 20,277 | Louisville | Ky. | KFC Yum! Center | |||||
| 11/07/2012 | H | Bellarmine (Exhibition) | 2 | W | 65 | 46 | 20,422 | Louisville | Ky. | KFC Yum! Center | |||||
| 11/11/2012 | H | Manhattan | 2 | W | 79 | 51 | 1-0 | 0-0 | 20,921 | Louisville | Ky. | KFC Yum! Center | |||
| 11/15/2012 | H | Samford | 2 | W | 80 | 54 | 2-0 | 0-0 | 20,016 | Louisville | Ky. | KFC Yum! Center | 2012 Battle 4 Atlantis | ||
| 11/18/2012 | H | Miami, Ohio | 2 | W | 80 | 39 | 3-0 | 0-0 | 20,258 | Louisville | Ky. | KFC Yum! Center | |||
| 11/22/2012 | N | Northern Iowa | 2 | W | 51 | 46 | 4-0 | 0-0 | 3,126 | Paradise Island | Bahamas | Imperial Arena | 2012 Battle 4 Atlantis | ||
| 11/23/2012 | N | 13 | Missouri | 2 | W | 84 | 61 | 5-0 | 0-0 | 3,153 | Paradise Island | Bahamas | Imperial Arena | 2012 Battle 4 Atlantis | |
| 11/24/2012 | N | 5 | Duke | 2 | L | 71 | 76 | 5-1 | 0-0 | 3,511 | Paradise Island | Bahamas | Imperial Arena | 2012 Battle 4 Atlantis | |
| 12/01/2012 | H | Illinois State | 5 | W | 69 | 66 | 6-1 | 0-0 | 19,816 | Louisville | Ky. | KFC Yum! Center | |||
| 12/04/2012 | A | College of Charleston | 5 | W | 80 | 38 | 7-1 | 0-0 | 5,117 | Charleston | S.C. | TD Arena | |||
| 12/08/2012 | H | Missouri-Kansas City | 5 | W | 99 | 47 | 8-1 | 0-0 | 20,074 | Louisville | Ky. | KFC Yum! Center | |||
| 12/15/2012 | A | Memphis | 6 | W | 87 | 78 | 9-1 | 0-0 | 18,392 | Memphis | Tenn. | FedEx Forum | |||
| 12/19/2012 | H | Florida International | 5 | W | 79 | 55 | 10-1 | 0-0 | 21,411 | Louisville | Ky. | KFC Yum! Center | 2012 Billy Minardi Classic | ||
| 12/22/2012 | N | Western Kentucky | 5 | W | 78 | 55 | 11-1 | 0-0 | 10,728 | Nashville | Tenn. | Bridgestone Arena | |||
| 12/29/2012 | H | Kentucky | 4 | W | 80 | 77 | 12-1 | 0-0 | 22,810 | Louisville | Ky. | KFC Yum! Center | |||
| 01/02/2013 | H | Providence | 4 | W | 80 | 62 | 13-1 | 1-0 | 21,305 | Louisville | Ky. | KFC Yum! Center | |||
| 01/09/2013 | A | Seton Hall | 3 | W | 73 | 58 | 14-1 | 2-0 | 7,013 | Newark | N.J. | Prudential Center | |||
| 01/12/2013 | H | South Florida | 3 | W | 64 | 38 | 15-1 | 3-0 | 21,903 | Louisville | Ky. | KFC Yum! Center | |||
| 01/14/2013 | A | Connecticut | 1 | W | 73 | 58 | 16-1 | 4-0 | 14,287 | Hartford | Conn. | XL Center | |||
| 01/19/2013 | H | 6 | Syracuse | 1 | L | 68 | 70 | 16-2 | 4-1 | 22,814 | Louisville | Ky. | KFC Yum! Center | ||
| 01/22/2013 | A | Villanova | 5 | L | 64 | 73 | 16-3 | 4-2 | 11,887 | Philadelphia | Pa. | Wells Fargo Center | |||
| 01/26/2013 | A | Georgetown | 5 | L | 51 | 53 | 16-4 | 4-3 | 17,474 | Washington | D.C. | Verizon Center | |||
| 01/28/2013 | H | Pittsburgh | 12 | W | 64 | 61 | 17-4 | 5-3 | 22,411 | Louisville | Ky. | KFC Yum! Center | |||
| 02/03/2013 | H | 25 | Marquette | 12 | W | 70 | 51 | 18-4 | 6-3 | 21,418 | Louisville | Ky. | KFC Yum! Center | ||
| 02/06/2013 | A | Rutgers | 11 | W | 68 | 48 | 19-4 | 7-3 | 5,862 | Piscataway | N.J. | Louis Brown Athletic Center | |||
| 02/09/2013 | A | 25 | Notre Dame | 11 | L | 101 | 104 | 5OT | 19-5 | 7-4 | 9,149 | South Bend | Ind. | Purcell Pavillion at Joyce Center | |
| 02/14/2013 | H | St. John's | 12 | W | 72 | 58 | 20-5 | 8-4 | 22,086 | Louisville | Ky. | KFC Yum! Center | |||
| 02/17/2013 | A | South Florida | 12 | W | 59 | 41 | 21-5 | 9-4 | 7,368 | Tampa | Fla. | USF Sun Dome | |||
| 02/23/2013 | H | Seton Hall | 10 | W | 79 | 61 | 22-5 | 10-4 | 22,332 | Louisville | Ky. | KFC Yum! Center | |||
| 02/27/2013 | A | DePaul | 10 | W | 79 | 58 | 23-5 | 11-4 | 8,654 | Rosemont | Ill. | Allstate Arena | |||
| 03/02/2013 | A | 12 | Syracuse | 10 | W | 58 | 53 | 24-5 | 12-4 | 31,173 | Syracuse | N.Y. | Carrier Dome | ||
| 03/04/2013 | H | Cincinnati | 8 | W | 67 | 51 | 25-5 | 13-4 | 22,739 | Louisville | Ky. | KFC Yum! Center | |||
| 03/09/2013 | H | 24 | Notre Dame | 8 | W | 73 | 57 | 26-5 | 14-4 | 22,815 | Louisville | Ky. | KFC Yum! Center | ||
| 03/14/2013 | N | Villanova | 4 | W | 74 | 55 | 27-5 | 14-4 | 20,057 | New York | N.Y. | Madison Square Garden IV | 2013 Big East Tournament Quarterfinal | ||
| 03/15/2013 | N | 24 | Notre Dame | 4 | W | 69 | 57 | 28-5 | 14-4 | 20,057 | New York | N.Y. | Madison Square Garden IV | 2013 Big East Tournament Semifinal | |
| 03/16/2013 | N | 19 | Syracuse | 4 | W | 78 | 61 | 29-5 | 14-4 | 20,057 | New York | N.Y. | Madison Square Garden IV | 2013 Big East Tournament Final | |
| 03/21/2013 | N | North Carolina A&T | 2 | W | 79 | 48 | 30-5 | 14-4 | 16,632 | Lexington | Ky. | Rupp Arena | 2013 NCAA Tournament Midwest Regional Second Round | ||
| 03/23/2013 | N | Colorado State | 2 | W | 82 | 56 | 31-5 | 14-4 | 20,601 | Lexington | Ky. | Rupp Arena | 2013 NCAA Tournament Midwest Regional Third Round | ||
| 03/29/2013 | N | 25 | Oregon | 2 | W | 77 | 69 | 32-5 | 14-4 | 35,520 | Indianapolis | Ind. | Lucas Oil Stadium | 2013 NCAA Tournament Midwest Regional Semifinal | |
| 03/31/2013 | N | 6 | Duke | 2 | W | 85 | 63 | 33-5 | 14-4 | 34,657 | Indianapolis | Ind. | Lucas Oil Stadium | 2013 NCAA Tournament Midwest Regional Final | |
| 04/06/2013 | N | Wichita State | 2 | W | 72 | 68 | 34-5 | 14-4 | 75,350 | Atlanta | Ga. | Georgia Dome | 2013 NCAA Tournament Seminfinal | ||
| 04/08/2013 | N | 10 | Michigan | 2 | W | 82 | 76 | 35-5 | 14-4 | 74,326 | Atlanta | Ga. | Georgia Dome | 2013 NCAA Tournament Final |