31 games, 1 exhibition
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 10/29/2019 | H | Bellarmine (Exhibition) | 5 | W | 75 | 65 | 15,009 | Louisville | Ky. | KFC Yum! Center | |||||
| 11/05/2019 | A | Miami, Fla. | 5 | W | 87 | 74 | 1-0 | 1-0 | 7,576 | Coral Gables | Fla. | Watsco Center | |||
| 11/10/2019 | H | Youngstown State | 5 | W | 78 | 55 | 2-0 | 1-0 | 14,761 | Louisville | Ky. | KFC Yum! Center | 2019 Global Sports Shootout | ||
| 11/13/2019 | H | Indiana State | 4 | W | 91 | 62 | 3-0 | 1-0 | 14,808 | Louisville | Ky. | KFC Yum! Center | |||
| 11/17/2019 | H | North Carolina Central | 4 | W | 87 | 58 | 4-0 | 1-0 | 14,874 | Louisville | Ky. | KFC Yum! Center | 2019 Global Sports Shootout | ||
| 11/20/2019 | H | South Carolina Upstate | 2 | W | 76 | 50 | 5-0 | 1-0 | 14,410 | Louisville | Ky. | KFC Yum! Center | 2019 Global Sports Shootout | ||
| 11/24/2019 | H | Akron | 2 | W | 82 | 76 | 6-0 | 1-0 | 14,889 | Louisville | Ky. | KFC Yum! Center | 2019 Global Sports Shootout | ||
| 11/29/2019 | N | Western Kentucky | 2 | W | 71 | 54 | 7-0 | 1-0 | 12,863 | Nashville | Tenn. | Bridgestone Arena | |||
| 12/03/2019 | H | 4 | Michigan | 1 | W | 58 | 43 | 8-0 | 1-0 | 21,674 | Louisville | Ky. | KFC Yum! Center | 2019 Big Ten-ACC Challenge | |
| 12/06/2019 | H | Pittsburgh | 1 | W | 64 | 46 | 9-0 | 2-0 | 17,249 | Louisville | Ky. | KFC Yum! Center | |||
| 12/10/2019 | N | Texas Tech | 1 | L | 57 | 70 | 9-1 | 2-0 | 10,945 | New York | N.Y. | Madison Square Garden IV | 2019 Jimmy V Classic | ||
| 12/14/2019 | H | Eastern Kentucky | 1 | W | 99 | 67 | 10-1 | 2-0 | 16,185 | Louisville | Ky. | KFC Yum! Center | |||
| 12/18/2019 | H | Miami, Ohio | 3 | W | 70 | 46 | 11-1 | 2-0 | 15,444 | Louisville | Ky. | KFC Yum! Center | |||
| 12/28/2019 | A | 19 | Kentucky | 3 | L | 70 | 78 | OT | 11-2 | 2-0 | 20,437 | Louisville | Ky. | Rupp Arena | |
| 01/04/2020 | H | 18 | Florida State | 7 | L | 65 | 78 | 11-3 | 2-1 | 17,786 | Louisville | Ky. | KFC Yum! Center | ||
| 01/07/2020 | H | Miami, Fla. | 13 | W | 74 | 58 | 12-3 | 3-1 | 14,980 | Louisville | Ky. | KFC Yum! Center | |||
| 01/11/2020 | A | Notre Dame | 13 | W | 67 | 64 | 13-3 | 4-1 | 8,404 | South Bend | Ind. | Joyce Athletic and Convocation Center | |||
| 01/14/2020 | A | Pittsburgh | 11 | W | 73 | 68 | OT | 14-3 | 5-1 | 9,221 | Pittsburgh | Pa. | Petersen Events Center | ||
| 01/18/2020 | A | 3 | Duke | 11 | W | 79 | 73 | 15-3 | 6-1 | 9,314 | Durham | N.C. | Cameron Indoor Stadium | ||
| 01/22/2020 | H | Georgia Tech | 6 | W | 68 | 64 | 16-3 | 7-1 | 15,001 | Louisville | Ky. | KFC Yum! Center | |||
| 01/25/2020 | H | Clemson | 6 | W | 80 | 62 | 17-3 | 8-1 | 17,654 | Louisville | Ky. | KFC Yum! Center | |||
| 01/29/2020 | A | Boston College | 6 | W | 86 | 69 | 18-3 | 9-1 | 5,771 | Chestnut Hill | Mass. | Conte Forum | |||
| 02/01/2020 | A | North Carolina State | 6 | W | 77 | 57 | 19-3 | 10-1 | 18,197 | Raleigh | N.C. | PNC Arena | |||
| 02/05/2020 | H | Wake Forest | 5 | W | 86 | 76 | 20-3 | 11-1 | 15,270 | Louisville | Ky. | KFC Yum! Center | |||
| 02/08/2020 | H | Virginia | 5 | W | 80 | 73 | 21-3 | 12-1 | 19,250 | Louisville | Ky. | KFC Yum! Center | |||
| 02/12/2020 | A | Georgia Tech | 5 | L | 58 | 64 | 21-4 | 12-2 | 5,801 | Atlanta | Ga. | McCamish Pavilion | |||
| 02/15/2020 | A | Clemson | 5 | L | 62 | 77 | 21-5 | 12-3 | 9,146 | Clemson | S.C. | Littlejohn Coliseum | |||
| 02/19/2020 | H | Syracuse | 11 | W | 90 | 66 | 22-5 | 13-3 | 16,428 | Louisville | Ky. | KFC Yum! Center | |||
| 02/22/2020 | H | North Carolina | 11 | W | 72 | 55 | 23-5 | 14-3 | 21,079 | Louisville | Ky. | KFC Yum! Center | |||
| 02/24/2020 | A | 6 | Florida State | 11 | L | 67 | 82 | 23-6 | 14-4 | 11,500 | Tallahassee | Fla. | Donald L. Tucker Civic Center | ||
| 03/01/2020 | H | Virginia Tech | 11 | W | 68 | 52 | 24-6 | 15-4 | 18,104 | Louisville | Ky. | KFC Yum! Center | |||
| 03/07/2020 | A | 22 | Virginia | 10 | L | 54 | 57 | 24-7 | 15-5 | 14,629 | Charlottesville | Va. | John Paul Jones Arena |