Series record: 11-7 (Home: 7-2, Away: 4-5, Neutral: 0-0)
18 games
| Date | Site | Opp AP | UL AP | W/L | UL | Opp | OT | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 10/18/1986 | A | L | 7 | 41 | 28,105 | Chestnut Hill | Mass. | Alumni Stadium | ||||
| 11/18/1989 | A | W | 36 | 22 | 24,650 | Chestnut Hill | Mass. | Alumni Stadium | ||||
| 11/10/1990 | H | 22 | W | 17 | 10 | 37,636 | Louisville | Ky. | Cardinal Stadium | |||
| 10/12/1991 | A | L | 3 | 33 | 27,839 | Chestnut Hill | Mass. | Alumni Stadium | ||||
| 11/03/1994 | H | L | 14 | 35 | 38,711 | Louisville | Ky. | Cardinal Stadium | ||||
| 09/26/1998 | H | W | 52 | 28 | 38,231 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 11/08/2014 | A | RV | W | 38 | 19 | 33,565 | Chestnut Hill | Mass. | Alumni Stadium | |||
| 10/24/2015 | H | W | 17 | 14 | 41,486 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 11/05/2016 | A | 5 | W | 52 | 7 | 30,644 | Chestnut Hill | Mass. | Alumni Stadium | |||
| 10/14/2017 | H | L | 42 | 45 | 44,679 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 10/13/2018 | A | L | 20 | 38 | 31,478 | Chestnut Hill | Mass. | Alumni Stadium | ||||
| 10/05/2019 | H | W | 41 | 39 | 46,007 | Louisville | Ky. | Cardinal Stadium | ||||
| 11/28/2020 | A | L | 27 | 34 | 0 | Chestnut Hill | Mass. | Alumni Stadium | ||||
| 10/23/2021 | H | W | 28 | 14 | 38,202 | Louisville | Ky. | Cardinal Stadium | ||||
| 10/01/2022 | A | L | 33 | 34 | 38,517 | Chestnut Hill | Mass. | Alumni Stadium | ||||
| 09/23/2023 | H | W | 56 | 28 | 48,294 | Louisville | Ky. | L&N Federal Credit Union Stadium | ||||
| 10/25/2024 | A | W | 31 | 27 | 42,887 | Chestnut Hill | Mass. | Alumni Stadium | ||||
| 10/25/2025 | H | 19 | W | 38 | 24 | 50,320 | Louisville | Ky. | L&N Federal Credit Union Stadium |