Series record: 8-9 (Home: 5-4, Away: 3-5, Neutral: 0-0)
17 games
| Date | Site | Opp AP | UL AP | W/L | UL | Opp | OT | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 10/14/1950 | A | L | 7 | 27 | 5,000 | Houston | Texas | Houston Public School Stadium | ||||
| 11/10/1951 | H | W | 35 | 28 | 3,000 | Louisville | Ky. | duPont Manual Stadium | ||||
| 11/24/1962 | H | L | 25 | 27 | 4,126 | Louisville | Ky. | Fairgrounds Stadium | ||||
| 12/14/1963 | A | L | 7 | 21 | 5,000 | Houston | Texas | Rice Stadium | ||||
| 09/29/1984 | A | W | 30 | 28 | 22,533 | Houston | Texas | Astrodome | ||||
| 09/28/1985 | H | L | 27 | 49 | 30,334 | Louisville | Ky. | Cardinal Stadium | ||||
| 11/16/1996 | A | L | 7 | 38 | 19,651 | Houston | Texas | Astrodome | ||||
| 10/25/1997 | H | L | 22 | 36 | 21,432 | Louisville | Ky. | Cardinal Stadium | ||||
| 10/23/1999 | H | W | 39 | 33 | 27,261 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 11/18/2000 | A | W | 32 | 13 | 3,006 | Houston | Texas | Robertson Stadium | ||||
| 11/10/2001 | H | 25 | W | 34 | 10 | 40,479 | Louisville | Ky. | Papa John's Cardinal Stadium | |||
| 11/30/2002 | A | L | 10 | 27 | 11,048 | Houston | Texas | Robertson Stadium | ||||
| 11/22/2003 | H | W | 66 | 45 | 33,268 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 11/20/2004 | A | 8 | W | 65 | 27 | 20,176 | Houston | Texas | Robertson Stadium | |||
| 11/16/2013 | H | RV | 19 | W | 20 | 13 | 53,027 | Louisville | Ky. | Papa John's Cardinal Stadium | ||
| 09/12/2015 | H | RV | L | 31 | 34 | 50,019 | Louisville | Ky. | Papa John's Cardinal Stadium | |||
| 11/17/2016 | A | 3 | L | 10 | 36 | 42,822 | Houston | Texas | TDECU Stadium |