Series record: 5-3 (Home: 2-1, Away: 3-2, Neutral: 0-0)
8 games
| Date | Site | Opp AP | UL AP | W/L | UL | Opp | OT | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/24/1988 | A | W | 38 | 34 | 49,900 | Chapel Hill | N.C. | Kenan Stadium | ||||
| 09/21/1995 | H | L | 10 | 17 | 37,704 | Louisville | Ky. | Cardinal Stadium | ||||
| 11/09/1996 | A | L | 10 | 28 | 46,000 | Chapel Hill | N.C. | Kenan Stadium | ||||
| 09/25/2004 | A | 24 | W | 34 | 0 | 49,000 | Chapel Hill | N.C. | Kenan Stadium | |||
| 10/08/2005 | H | RV | 23 | W | 69 | 14 | 41,334 | Louisville | Ky. | Papa John's Cardinal Stadium | ||
| 10/08/2011 | A | L | 7 | 14 | 51,500 | Chapel Hill | N.C. | Kenan Stadium | ||||
| 09/15/2012 | H | RV | 19 | W | 39 | 34 | 53,334 | Louisville | Ky. | Papa John's Cardinal Stadium | ||
| 09/09/2017 | A | 17 | W | 47 | 35 | 47,000 | Chapel Hill | N.C. | Kenan Stadium |