Series record: 7-5 (Home: 5-1, Away: 2-4, Neutral: 0-0)
12 games
| Date | Site | Opp AP | UL AP | W/L | UL | Opp | OT | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 10/04/2003 | A | RV | L | 28 | 31 | 2 OT | 36,044 | Tampa | Fla. | Raymond James Stadium | ||
| 10/22/2004 | H | 15 | W | 41 | 9 | 42,032 | Louisville | Ky. | Papa John's Cardinal Stadium | |||
| 09/24/2005 | A | 9 | L | 14 | 45 | 33,586 | Tampa | Fla. | Raymond James Stadium | |||
| 11/18/2006 | H | 10 | W | 31 | 8 | 40,348 | Louisville | Ky. | Papa John's Cardinal Stadium | |||
| 11/17/2007 | A | RV | L | 17 | 55 | 57,288 | Tampa | Fla. | Raymond James Stadium | |||
| 10/25/2008 | H | 14 | W | 24 | 20 | 40,384 | Louisville | Ky. | Papa John's Cardinal Stadium | |||
| 11/21/2009 | A | L | 22 | 34 | 49,388 | Tampa | Fla. | Raymond James Stadium | ||||
| 11/13/2010 | H | L | 21 | 24 | OT | 43,887 | Louisville | Ky. | Papa John's Cardinal Stadium | |||
| 11/25/2011 | A | W | 34 | 24 | 33,416 | Tampa | Fla. | Raymond James Stadium | ||||
| 10/20/2012 | H | 16 | W | 27 | 25 | 50,167 | Louisville | Ky. | Papa John's Cardinal Stadium | |||
| 10/26/2013 | A | 18 | W | 34 | 3 | 35,782 | Tampa | Fla. | Raymond James Stadium | |||
| 09/24/2022 | H | W | 41 | 3 | 41,217 | Louisville | Ky. | Cardinal Stadium |