Series record: 4-6 (Home: 3-2, Away: 1-3, Neutral: 0-1)
10 games
| Date | Site | Opp AP | UL AP | W/L | UL | Opp | OT | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/08/1979 | H | L | 14 | 15 | 29,436 | Louisville | Ky. | Fairgrounds Stadium | ||||
| 10/01/1983 | A | L | 0 | 31 | 28,300 | Blacksburg | Va. | Lane Stadium | ||||
| 11/09/1985 | A | L | 17 | 41 | 28,300 | Blacksburg | Va. | Lane Stadium | ||||
| 11/05/1988 | H | W | 13 | 3 | 21,107 | Louisville | Ky. | Cardinal Stadium | ||||
| 10/26/1991 | A | L | 13 | 41 | 45,662 | Blacksburg | Va. | Lane Stadium | ||||
| 10/10/1992 | H | W | 21 | 17 | 29,418 | Louisville | Ky. | Cardinal Stadium | ||||
| 01/02/2006 | N | 12 | 15 | L | 24 | 35 | 63,780 | Jacksonville | Fla. | Alltel Stadium | Gator Bowl | |
| 10/31/2020 | H | L | 35 | 42 | 11,901 | Louisville | Ky. | Cardinal Stadium | ||||
| 11/04/2023 | H | 15 | W | 34 | 3 | 49,945 | Louisville | Ky. | L&N Federal Credit Union Stadium | |||
| 11/01/2025 | A | 16 | W | 28 | 16 | 54,030 | Blacksburg | Va. | Lane Stadium |