8 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 10/03/1925 | H | Evansville | W | 20 | 0 | 1-0 | Louisville | Ky. | Maxwell Field | ||||||
| 10/10/1925 | A | Western Kentucky | W | 6 | 0 | 2-0 | Bowling Green | Ky. | Bowling Green Fairgrounds | ||||||
| 10/17/1925 | A | Hanover | W | 24 | 0 | 3-0 | Hanover | Ind. | |||||||
| 10/24/1925 | H | Kentucky Wesleyan | W | 6 | 0 | 4-0 | Louisville | Ky. | Parkway Field | ||||||
| 10/30/1925 | A | Transylvania | W | 7 | 0 | 5-0 | 1,200 | Lexington | Ky. | Thomas Field | |||||
| 11/07/1925 | H | Rose Poly | W | 30 | 0 | 6-0 | Louisville | Ky. | Parkway Field | ||||||
| 11/21/1925 | H | Toledo | W | 34 | 0 | 7-0 | Louisville | Ky. | Parkway Field | ||||||
| 11/26/1925 | A | Marshall | W | 7 | 2 | 8-0 | Huntington | W.Va. |