8 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/22/1941 | H | Rio Grande | W | 58 | 0 | 1-0 | Louisville | Ky. | Maxwell Field | ||||||
| 09/27/1941 | A | Cincinnati | L | 7 | 28 | 1-1 | Cincinnati | Ohio | Nippert Stadium | ||||||
| 10/04/1941 | H | Evansville | W | 31 | 6 | 2-1 | Louisville | Ky. | Maxwell Field | ||||||
| 10/17/1941 | A | Transylvania | W | 13 | 0 | 3-1 | 1-0 | 2,500 | Lexington | Ky. | Thomas Field | ||||
| 10/23/1941 | H | Georgetown, Ky. | L | 7 | 19 | 3-2 | 1-1 | 4,500 | Louisville | Ky. | Maxwell Field | ||||
| 11/01/1941 | A | DePauw | L | 6 | 13 | 3-3 | 1-1 | Greencastle | Ind. | Blackstock Stadium | |||||
| 11/08/1941 | A | Hanover | W | 21 | 6 | 4-3 | 1-1 | Hanover | Ind. | ||||||
| 11/15/1941 | H | Vanderbilt | L | 0 | 68 | 4-4 | 1-1 | 4,000 | Louisville | Ky. | duPont Manual Stadium |