10 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/18/1965 | A | Western Michigan | L | 13 | 17 | 0-1 | 13,000 | Kalamazoo | Mich. | Waldo Stadium | |||||
| 09/25/1965 | H | Southern Illinois | W | 13 | 0 | 1-1 | 7,200 | Louisville | Ky. | Fairgrounds Stadium | |||||
| 10/02/1965 | A | North Texas | W | 29 | 21 | 2-1 | 1-0 | 5,000 | Denton | Texas | Fouts Field | ||||
| 10/09/1965 | H | Dayton | W | 34 | 0 | 3-1 | 2-0 | 7,800 | Louisville | Ky. | Fairgrounds Stadium | ||||
| 10/16/1965 | H | East Carolina | L | 20 | 34 | 3-2 | 2-0 | 8,800 | Louisville | Ky. | Fairgrounds Stadium | ||||
| 10/23/1965 | H | Marshall | W | 23 | 7 | 4-2 | 2-0 | 6,800 | Louisville | Ky. | Fairgrounds Stadium | ||||
| 10/30/1965 | H | Wichita State | W | 30 | 10 | 5-2 | 3-0 | 7,900 | Louisville | Ky. | Fairgrounds Stadium | ||||
| 11/06/1965 | A | Tulsa | L | 18 | 51 | 5-3 | 3-1 | 35,783 | Tulsa | Okla. | |||||
| 11/13/1965 | A | Drake | W | 32 | 17 | 6-3 | 3-1 | 3,500 | Des Moines | Iowa | Drake Stadium | ||||
| 11/20/1965 | A | Kent State | L | 6 | 7 | 6-4 | 3-1 | 5,700 | Kent | Ohio | Memorial Stadium |