12 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/10/1977 | H | Northern Illinois | W | 38 | 0 | 1-0 | 16,453 | Louisville | Ky. | Fairgrounds Stadium | |||||
| 09/17/1977 | H | Cincinnati | T | 17 | 17 | 1-0-1 | 25,384 | Louisville | Ky. | Fairgrounds Stadium | |||||
| 09/24/1977 | H | William & Mary | L | 7 | 21 | 1-1-1 | 20,571 | Louisville | Ky. | Fairgrounds Stadium | |||||
| 10/01/1977 | A | Memphis | W | 14 | 13 | 2-1-1 | 22,750 | Memphis | Tenn. | Liberty Bowl Memorial Stadium | |||||
| 10/08/1977 | H | Tulsa | W | 33 | 0 | 3-1-1 | 12,007 | Louisville | Ky. | Fairgrounds Stadium | |||||
| 10/15/1977 | A | Dayton | L | 10 | 14 | 3-2-1 | 11,091 | Dayton | Ohio | Welcome Stadium | |||||
| 10/22/1977 | A | 3 | Alabama | L | 6 | 55 | 3-3-1 | 60,210 | Tuscaloosa | Ala. | Bryant-Denny Stadium | ||||
| 10/29/1977 | A | Marshall | W | 56 | 0 | 4-3-1 | 10,232 | Huntington | W.Va. | Fairfield Stadium | |||||
| 11/05/1977 | H | Wichita State | W | 51 | 21 | 5-3-1 | 12,031 | Louisville | Ky. | Fairgrounds Stadium | |||||
| 11/12/1977 | H | Drake | W | 18 | 13 | 6-3-1 | 12,247 | Louisville | Ky. | Fairgrounds Stadium | |||||
| 11/20/1977 | H | Indiana State | W | 27 | 16 | 7-3-1 | 11,847 | Louisville | Ky. | Fairgrounds Stadium | |||||
| 12/17/1977 | N | Louisiana Tech | L | 14 | 24 | 7-4-1 | 18,500 | Shreveport | La. | State Fair Stadium | Independence Bowl |