11 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/09/1978 | H | South Dakota State | W | 54 | 7 | 1-0 | 21,109 | Louisville | Ky. | Fairgrounds Stadium | |||||
| 09/16/1978 | H | 20 | Maryland | L | 17 | 24 | 1-1 | 36,124 | Louisville | Ky. | Fairgrounds Stadium | ||||
| 09/23/1978 | A | Cincinnati | W | 28 | 14 | 2-1 | 21,709 | Cincinnati | Ohio | Nippert Stadium | |||||
| 09/30/1978 | H | Indiana State | W | 31 | 12 | 3-1 | 16,931 | Louisville | Ky. | Fairgrounds Stadium | |||||
| 10/07/1978 | A | Tulsa | L | 7 | 24 | 3-2 | 20,500 | Tulsa | Okla. | Skelly Stadium | |||||
| 10/14/1978 | H | Northwest Louisiana | W | 51 | 7 | 4-2 | 13,372 | Louisville | Ky. | Fairgrounds Stadium | |||||
| 10/21/1978 | H | Boston University | W | 35 | 7 | 5-2 | 15,886 | Louisville | Ky. | Fairgrounds Stadium | |||||
| 10/28/1978 | H | William & Mary | W | 33 | 21 | 6-2 | 17,879 | Louisville | Ky. | Fairgrounds Stadium | |||||
| 11/04/1978 | A | Wichita State | W | 38 | 20 | 7-2 | 10,812 | Wichita | Kan. | Cessna Stadium | |||||
| 11/11/1978 | H | Memphis | L | 22 | 29 | 7-3 | 17,012 | Louisville | Ky. | Fairgrounds Stadium | |||||
| 11/18/1978 | A | Southern Mississippi | L | 3 | 37 | 7-4 | 16,219 | Hattiesburg | Miss. | Roberts Stadium |