11 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1921-01-07 | A | Cincinnati | L | 16 | 36 | 0-1 | ||||||||
| 1921-01-08 | A | Cincinnati Gym | L | 12 | 29 | 0-2 | ||||||||
| 1921-01-15 | H | Centre | L | 20 | 34 | 0-3 | Louisville | KY | YMCA Gymnasium | |||||
| 1921-01-22 | H | Chattanooga | L | 28 | 33 | 0-4 | Louisville | KY | St. Xavier Gymnasium | |||||
| 1921-02-01 | H | Butler | L | 24 | 62 | 0-5 | New Albany | IN | Calumet Club | |||||
| 1921-02-04 | A | Indiana | L | 17 | 34 | 0-6 | Bloomington | IN | ||||||
| 1921-02-08 | A | Transylvania | L | 15 | 29 | 0-7 | ||||||||
| 1921-02-11 | H | Cumberland | W | 35 | 20 | 1-7 | Louisville | KY | YMCA Gymnasium | |||||
| 1921-02-18 | H | Georgetown College | W | 30 | 29 | 2-7 | Louisville | KY | ||||||
| 1921-02-26 | H | Transylvania | W | 24 | 20 | 3-7 | Louisville | KY | St. Xavier Gymnasium | |||||
| 1921-03-01 | A | Louisville YMHA | L | 30 | 41 | 3-8 | Louisville | KY | YMHA Gymnasium |