32 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1949-12-03 | H | Kentucky Wesleyan | W | 69 | 44 | 1-0 | Louisville | KY | Jefferson County Armory | |||||
| 1949-12-03 | H | Georgetown College | W | 57 | 47 | 2-0 | Louisville | KY | Jefferson County Armory | |||||
| 1949-12-05 | A | Indiana State | W | 68 | 66 | 3-0 | Terre Haute | IN | ||||||
| 1949-12-07 | H | Memphis | W | 79 | 58 | 4-0 | Louisville | KY | Jefferson County Armory | |||||
| 1949-12-10 | H | Morehead State | W | 82 | 48 | 5-0 | Louisville | KY | Jefferson County Armory | |||||
| 1949-12-13 | A | Eastern Kentucky | L | 54 | 62 | 5-1 | Richmond | KY | ||||||
| 1949-12-14 | H | Loyola, Calif. | W | 47 | 46 | 6-1 | Louisville | KY | Jefferson County Armory | |||||
| 1949-12-17 | A | Xavier | W | 64 | 47 | 7-1 | Cincinnati | OH | ||||||
| 1949-12-19 | H | Denver | W | 81 | 70 | 8-1 | Louisville | KY | Jefferson County Armory | |||||
| 1949-12-22 | N | Louisiana State | W | 75 | 65 | 9-1 | New Albany | IN | New Albany High School Gym | |||||
| 1949-12-29 | H | Evansville | L | 73 | 76 | 9-2 | Louisville | KY | Jefferson County Armory | |||||
| 1950-01-02 | H | Tennessee | W | 74 | 63 | 10-2 | Louisville | KY | Jefferson County Armory | |||||
| 1950-01-05 | A | Kentucky Wesleyan | W | 77 | 50 | 11-2 | Winchester | KY | ||||||
| 1950-01-07 | H | Xavier | W | 77 | 72 | 12-2 | Louisville | KY | Jefferson County Armory | |||||
| 1950-01-11 | H | 14 | Western Kentucky | W | 70 | 59 | 13-2 | Louisville | KY | Jefferson County Armory | ||||
| 1950-01-14 | H | Washington, Mo. | W | 67 | 44 | 14-2 | Louisville | KY | Jefferson County Armory | |||||
| 1950-01-16 | A | Georgetown College | 19 | W | 94 | 63 | 15-2 | Georgetown | KY | |||||
| 1950-01-18 | H | Eastern Kentucky | 19 | W | 73 | 62 | 16-2 | Louisville | KY | Jefferson County Armory | ||||
| 1950-01-21 | A | Marshall | 19 | L | 72 | 96 | 16-3 | Huntington | WV | |||||
| 1950-01-23 | A | Morehead State | W | 82 | 71 | 17-3 | Morehead | KY | ||||||
| 1950-01-25 | A | 10 | North Carolina State | L | 53 | 79 | 17-4 | Raleigh | NC | |||||
| 1950-01-27 | A | Seton Hall | W | 82 | 69 | 18-4 | South Orange | NJ | ||||||
| 1950-01-28 | A | 19 | Villanova | W | 78 | 68 | 19-4 | Philadelphia | PA | |||||
| 1950-02-03 | A | 14 | Western Kentucky | 15 | L | 62 | 84 | 19-5 | Bowling Green | KY | ||||
| 1950-02-04 | H | 2 | Duquesne | 15 | W | 64 | 58 | 20-5 | Louisville | KY | Jefferson County Armory | |||
| 1950-02-06 | A | Washington, Mo. | 13 | L | 57 | 61 | 20-6 | 3,000 | St. Louis | MO | ||||
| 1950-02-08 | A | Denver | 13 | L | 70 | 79 | 20-7 | Denver | CO | |||||
| 1950-02-10 | A | Loyola, Calif. | 13 | L | 47 | 68 | 20-8 | Los Angeles | CA | |||||
| 1950-02-11 | A | Pepperdine | 13 | L | 62 | 65 | 20-9 | Los Angeles | CA | |||||
| 1950-02-13 | H | Marshall | W | 74 | 66 | 21-9 | Louisville | KY | Jefferson County Armory | |||||
| 1950-02-15 | N | Evansville | L | 61 | 79 | 21-10 | Owensboro | KY | Owensboro Sports Center | |||||
| 1950-02-18 | H | 8 | North Carolina State | L | 52 | 66 | 21-11 | Louisville | KY | Jefferson County Armory |