26 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1965-12-01 | H | Georgetown College | W | 77 | 58 | 1-0 | 0-0 | 9,460 | Louisville | KY | Freedom Hall | |||
| 1965-12-04 | H | Central Missouri State | W | 81 | 72 | 2-0 | 0-0 | 9,900 | Louisville | KY | Freedom Hall | |||
| 1965-12-08 | A | DePaul | L | 62 | 87 | 2-1 | 0-0 | IL | ||||||
| 1965-12-11 | H | Marquette | W | 70 | 61 | 3-1 | 0-0 | 8,900 | Louisville | KY | Freedom Hall | |||
| 1965-12-15 | A | Dayton | L | 59 | 76 | 3-2 | 0-0 | |||||||
| 1965-12-18 | H | Bellarmine | W | 82 | 52 | 4-2 | 0-0 | 8,800 | Louisville | KY | Freedom Hall | |||
| 1965-12-22 | H | Army | W | 84 | 56 | 5-2 | 0-0 | 13,000 | Louisville | KY | Freedom Hall | |||
| 1965-12-27 | N | Georgia Tech | W | 54 | 48 | 6-2 | 0-0 | Miami Beach | FL | Convention Hall | 1965 Hurricane Classic | |||
| 1965-12-28 | A | Miami, Fla. | W | 85 | 84 | 7-2 | 0-0 | 4,029 | Miami Beach | FL | Convention Hall | 1965 Hurricane Classic | ||
| 1966-01-01 | H | Saint Louis | W | 84 | 80 | 8-2 | 1-0 | 9,600 | Louisville | KY | Freedom Hall | |||
| 1966-01-06 | A | Tulsa | L | 79 | 84 | 8-3 | 1-1 | Tulsa | OK | Tulsa Fairgrounds Pavilion | ||||
| 1966-01-08 | A | North Texas State | W | 70 | 58 | 9-3 | 2-1 | |||||||
| 1966-01-15 | A | 5 | Bradley | L | 62 | 79 | 9-4 | 2-2 | ||||||
| 1966-01-19 | H | Dayton | W | 94 | 77 | 10-4 | 2-2 | 11,264 | Louisville | KY | Freedom Hall | |||
| 1966-01-22 | H | Cincinnati | L | 65 | 67 | 10-5 | 2-3 | 12,198 | Louisville | KY | Freedom Hall | |||
| 1966-01-29 | H | Bradley | W | 103 | 71 | 11-5 | 3-3 | Louisville | KY | Freedom Hall | ||||
| 1966-02-01 | A | Saint Louis | L | 60 | 64 | 11-6 | 3-4 | |||||||
| 1966-02-05 | A | 10 | Cincinnati | L | 54 | 56 | 11-7 | 3-5 | ||||||
| 1966-02-10 | A | Drake | W | 57 | 53 | 12-7 | 4-5 | Des Moines | IA | Veterans Memorial Auditorium | ||||
| 1966-02-12 | A | Wichita State | L | 87 | 102 | 12-8 | 4-6 | |||||||
| 1966-02-17 | H | Tulsa | W | 64 | 50 | 13-8 | 5-6 | Louisville | KY | Freedom Hall | ||||
| 1966-02-19 | H | North Texas State | W | 105 | 93 | 14-8 | 6-6 | Louisville | KY | Freedom Hall | ||||
| 1966-02-24 | H | Drake | W | 79 | 70 | 15-8 | 7-6 | Louisville | KY | Freedom Hall | ||||
| 1966-02-26 | H | Wichita State | W | 81 | 66 | 16-8 | 8-6 | Louisville | KY | Freedom Hall | ||||
| 1966-03-02 | A | La Salle | L | 92 | 96 | 16-9 | 8-6 | |||||||
| 1966-03-12 | N | Boston College | L | 90 | 96 | 16-10 | 8-6 | 14,068 | New York | NY | Madison Square Garden III | 1966 NIT |