32 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1978-11-24 | N | Penn State | 4 | W | 89 | 58 | 1-0 | 0-0 | 2,500 | Anchorage | AK | Buckner Fieldhouse | 1978 Seawolf Classic | |
| 1978-11-25 | N | Lamar | 4 | W | 90 | 68 | 2-0 | 0-0 | 3,000 | Anchorage | AK | Buckner Fieldhouse | 1978 Seawolf Classic | |
| 1978-11-26 | N | 12 | North Carolina State | 4 | L | 66 | 72 | 2-1 | 0-0 | 3,600 | Anchorage | AK | Buckner Fieldhouse | 1978 Seawolf Classic |
| 1978-12-02 | H | Tennessee | 5 | W | 82 | 61 | 3-1 | 0-0 | 16,613 | Louisville | KY | Freedom Hall | ||
| 1978-12-06 | H | 6 | Michigan | 7 | W | 86 | 84 | 4-1 | 0-0 | 16,613 | Louisville | KY | Freedom Hall | |
| 1978-12-09 | H | Idaho | 7 | W | 101 | 54 | 5-1 | 0-0 | 14,038 | Louisville | KY | Freedom Hall | ||
| 1978-12-12 | A | Ohio State | 4 | L | 69 | 85 | 5-2 | 0-0 | 13,327 | Columbus | OH | St. John Arena | ||
| 1978-12-16 | H | West Virginia | 4 | W | 106 | 60 | 6-2 | 0-0 | 15,338 | Louisville | KY | Freedom Hall | ||
| 1978-12-23 | H | Providence | 12 | W | 88 | 70 | 7-2 | 0-0 | 16,075 | Louisville | KY | Freedom Hall | ||
| 1978-12-28 | H | Wisconsin | 10 | W | 70 | 53 | 8-2 | 0-0 | 12,961 | Louisville | KY | Freedom Hall | 1978 Louisville Holiday Classic | |
| 1978-12-29 | H | Mississippi State | 10 | L | 73 | 80 | 8-3 | 0-0 | 12,504 | Louisville | KY | Freedom Hall | 1978 Louisville Holiday Classic | |
| 1979-01-04 | H | Chattanooga | 16 | W | 94 | 70 | 9-3 | 0-0 | 12,467 | Louisville | KY | Freedom Hall | ||
| 1979-01-06 | H | Louisiana-Lafayette | 16 | W | 73 | 60 | 10-3 | 0-0 | 10,547 | Louisville | KY | Freedom Hall | ||
| 1979-01-08 | H | Marshall | 12 | W | 112 | 64 | 11-3 | 0-0 | 8,783 | Louisville | KY | Freedom Hall | ||
| 1979-01-13 | A | Maryland | 12 | W | 99 | 84 | 12-3 | 0-0 | 14,500 | College Park | MD | Cole Fieldhouse | ||
| 1979-01-16 | A | Dayton | 7 | W | 77 | 76 | 13-3 | 0-0 | 13,458 | Dayton | OH | University of Dayton Arena | ||
| 1979-01-18 | A | Cincinnati | 7 | W | 82 | 77 | 14-3 | 1-0 | 11,440 | Cincinnati | OH | Riverfront Coliseum | ||
| 1979-01-20 | A | Florida State | 7 | W | 67 | 65 | 15-3 | 2-0 | 3,119 | Tallahassee | FL | Tully Gymnasium | ||
| 1979-01-24 | H | Saint Louis | 5 | W | 80 | 65 | 16-3 | 3-0 | 13,911 | Louisville | KY | Freedom Hall | ||
| 1979-01-28 | H | Virginia Tech | 5 | W | 82 | 72 | 17-3 | 3-0 | 12,667 | Louisville | KY | Freedom Hall | ||
| 1979-01-31 | H | Florida State | 6 | W | 84 | 71 | 18-3 | 4-0 | 16,433 | Louisville | KY | Freedom Hall | ||
| 1979-02-03 | H | Cincinnati | 6 | W | 88 | 85 | 19-3 | 5-0 | 16,613 | Louisville | KY | Freedom Hall | ||
| 1979-02-05 | H | Memphis | 5 | W | 103 | 82 | 20-3 | 6-0 | 16,452 | Louisville | KY | Freedom Hall | ||
| 1979-02-08 | A | Tulane | 5 | W | 77 | 66 | 21-3 | 7-0 | 2,578 | New Orleans | LA | Superdome | ||
| 1979-02-10 | A | 9 | Marquette | 5 | L | 55 | 71 | 21-4 | 7-0 | 10,938 | Milwaukee | WI | Milwaukee Civic Center Arena | |
| 1979-02-15 | A | Saint Louis | 9 | W | 78 | 62 | 22-4 | 8-0 | 5,579 | St. Louis | MO | Checkerdome Arena | ||
| 1979-02-17 | A | Memphis | 9 | L | 53 | 60 | 22-5 | 8-1 | 10,165 | Memphis | TN | Mid-South Coliseum | ||
| 1979-02-18 | N | 5 | Duke | 9 | L | 72 | 88 | 22-6 | 8-1 | 3,866 | Charlotte | NC | Charlotte Coliseum | |
| 1979-02-24 | H | Tulane | 13 | W | 95 | 71 | 23-6 | 9-1 | 11,853 | Louisville | KY | Freedom Hall | ||
| 1979-03-02 | N | Virginia Tech | 13 | L | 68 | 72 | 23-7 | 9-1 | 9,167 | Memphis | TN | Mid-South Coliseum | 1979 Metro Tournament Semifinal | |
| 1979-03-10 | N | South Alabama | 18 | W | 69 | 66 | 24-7 | 9-1 | 9,681 | Dallas | TX | Moody Coliseum | 1979 NCAA Tournament Midwest Regional Second Round | |
| 1979-03-15 | N | 5 | Arkansas | 13 | L | 62 | 73 | 24-8 | 9-1 | 17,252 | Cincinnati | OH | Riverfront Coliseum | 1979 NCAA Tournament Midwest Regional Semifinal |