11 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/02/1989 | A | Wyoming | W | 28 | 21 | 1-0 | 26,132 | Laramie | Wyo. | War Memorial Stadium | |||||
| 09/09/1989 | A | Kansas | W | 33 | 28 | 2-0 | 32,700 | Lawrence | Kan. | Memorial Stadium | |||||
| 09/23/1989 | H | 9 | West Virginia | L | 21 | 30 | 2-1 | 39,132 | Louisville | Ky. | Cardinal Stadium | ||||
| 09/30/1989 | H | Cincinnati | W | 37 | 17 | 3-1 | 36,305 | Louisville | Ky. | Cardinal Stadium | |||||
| 10/14/1989 | H | Southern Mississippi | L | 10 | 16 | 3-2 | 38,484 | Louisville | Ky. | Cardinal Stadium | |||||
| 10/21/1989 | A | Tulsa | L | 24 | 31 | 3-3 | 20,012 | Tulsa | Okla. | Skelly Stadium | |||||
| 10/28/1989 | A | Virginia | L | 15 | 16 | 3-4 | 33,400 | Charlottesville | Va. | Scott Stadium | |||||
| 11/04/1989 | H | Western Kentucky | W | 55 | 7 | 4-4 | 36,126 | Louisville | Ky. | Cardinal Stadium | |||||
| 11/11/1989 | A | Memphis | W | 40 | 10 | 5-4 | 14,003 | Memphis | Tenn. | Liberty Bowl Memorial Stadium | |||||
| 11/18/1989 | A | Boston College | W | 36 | 22 | 6-4 | 24,650 | Chestnut Hill | Mass. | Alumni Stadium | |||||
| 12/02/1989 | N | Syracuse | L | 13 | 24 | 6-5 | 50,000 | Tokyo | Japan | Tokyo Dome | Coca-Cola Classic |