12 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/05/1998 | H | Kentucky | L | 34 | 68 | 0-1 | 42,643 | Louisville | Ky. | Papa John's Cardinal Stadium | |||||
| 09/12/1998 | A | Utah | L | 22 | 45 | 0-2 | 44,112 | Salt Lake City | Utah | Rice-Eccles Stadium | |||||
| 09/19/1998 | A | Illinois | W | 35 | 9 | 1-2 | 39,414 | Champaign | Ill. | Memorial Stadium | |||||
| 09/26/1998 | H | Boston College | W | 52 | 28 | 2-2 | 38,231 | Louisville | Ky. | Papa John's Cardinal Stadium | |||||
| 10/03/1998 | H | Cincinnati | W | 62 | 19 | 3-2 | 1-0 | 35,479 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 10/10/1998 | A | Southern Mississippi | L | 21 | 56 | 3-3 | 1-1 | 22,043 | Hattiesburg | Miss. | M. M. Roberts Stadium | ||||
| 10/17/1998 | A | Tulane | L | 22 | 28 | 3-4 | 1-2 | 26,217 | New Orleans | La. | Superdome | ||||
| 10/24/1998 | H | Memphis | W | 35 | 32 | 4-4 | 2-2 | 39,247 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 10/31/1998 | H | Western Kentucky | W | 63 | 34 | 5-4 | 2-2 | 32,649 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 11/14/1998 | A | East Carolina | W | 63 | 45 | 6-4 | 3-2 | 26,258 | Greenville | N.C. | |||||
| 11/21/1998 | H | Army | W | 35 | 23 | 7-4 | 4-2 | 40,349 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 12/23/1998 | N | Marshall | L | 29 | 48 | 7-5 | 4-2 | 52,016 | Pontiac | Mich. | Pontiac Silverdome | Motor City Bowl |