12 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/04/1999 | A | Kentucky | W | 56 | 28 | 1-0 | 70,692 | Lexington | Ky. | Commonwealth Stadium | |||||
| 09/11/1999 | H | Chattanooga | W | 58 | 30 | 2-0 | 38,147 | Louisville | Ky. | Papa John's Cardinal Stadium | |||||
| 09/18/1999 | H | Illinois | L | 36 | 41 | 2-1 | 40,332 | Louisville | Ky. | Papa John's Cardinal Stadium | |||||
| 09/25/1999 | H | Oklahoma | L | 21 | 42 | 2-2 | 41,214 | Louisville | Ky. | Papa John's Cardinal Stadium | |||||
| 10/02/1999 | H | Eastern Michigan | W | 45 | 10 | 3-2 | 33,879 | Louisville | Ky. | Papa John's Cardinal Stadium | |||||
| 10/07/1999 | A | Army | L | 52 | 59 | 2 OT | 3-3 | 0-1 | 26,535 | West Point | N.Y. | Michie Stadium | |||
| 10/16/1999 | A | Memphis | W | 32 | 31 | 4-3 | 1-1 | 30,315 | Memphis | Tenn. | Liberty Bowl Memorial Stadium | ||||
| 10/23/1999 | H | Houston | W | 39 | 33 | 5-3 | 2-1 | 27,261 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 10/30/1999 | H | Alabama-Birmingham | W | 23 | 14 | 6-3 | 3-1 | 34,786 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 11/06/1999 | A | Cincinnati | W | 23 | 13 | 7-3 | 4-1 | 26,399 | Cincinnati | Ohio | Nippert Stadium | ||||
| 11/20/1999 | H | 18 | Southern Mississippi | L | 27 | 30 | 7-4 | 4-2 | 41,826 | Louisville | Ky. | Papa John's Cardinal Stadium | |||
| 12/30/1999 | A | Boise State | L | 31 | 34 | 7-5 | 4-2 | 29,283 | Boise | Idaho | Bronco Stadium | Humanitarian Bowl |