13 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 08/23/2001 | H | New Mexico State | W | 45 | 24 | 1-0 | 38,129 | Louisville | Ky. | Papa John's Cardinal Stadium | |||||
| 09/01/2001 | A | Kentucky | W | 36 | 10 | 2-0 | 70,838 | Lexington | Ky. | Commonwealth Stadium | |||||
| 09/08/2001 | H | Western Carolina | W | 31 | 7 | 3-0 | 35,214 | Louisville | Ky. | Papa John's Cardinal Stadium | |||||
| 09/22/2001 | A | Illinois | 25 | L | 10 | 34 | 3-1 | 43,232 | Champaign | Ill. | Memorial Stadium | ||||
| 09/29/2001 | H | Memphis | W | 38 | 21 | 4-1 | 1-0 | 39,256 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 10/04/2001 | H | Colorado State | W | 7 | 2 | 5-1 | 1-0 | 39,389 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 10/16/2001 | H | Southern Mississippi | W | 24 | 14 | 6-1 | 2-0 | 33,627 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 10/27/2001 | A | Cincinnati | W | 28 | 13 | 7-1 | 3-0 | 31,004 | Cincinnati | Ohio | Nippert Stadium | ||||
| 11/03/2001 | A | Tulane | W | 52 | 7 | 8-1 | 4-0 | 19,369 | New Orleans | La. | Superdome | ||||
| 11/10/2001 | H | Houston | 25 | W | 34 | 10 | 9-1 | 5-0 | 40,479 | Louisville | Ky. | Papa John's Cardinal Stadium | |||
| 11/15/2001 | A | East Carolina | 19 | W | 39 | 34 | 10-1 | 6-0 | 39,775 | Greenville | N.C. | Dowdy-Ficklin Stadium | |||
| 11/23/2001 | A | Texas Christian | 17 | L | 22 | 37 | 10-2 | 6-1 | 22,176 | Fort Worth | Texas | Amon G. Carter Stadium | |||
| 12/31/2001 | N | 19 | Brigham Young | 23 | W | 28 | 10 | 11-2 | 6-1 | 58,968 | Memphis | Tenn. | Liberty Bowl Memorial Stadium | Liberty Bowl |