13 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/03/2006 | H | Kentucky | 13 | W | 59 | 28 | 1-0 | 42,597 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 09/09/2006 | A | Temple | 13 | W | 62 | 0 | 2-0 | 16,015 | Philadelphia | Pa. | Lincoln Financial Field | ||||
| 09/16/2006 | H | 17 | Miami, Fla. | 12 | W | 31 | 7 | 3-0 | 42,704 | Louisville | Ky. | Papa John's Cardinal Stadium | |||
| 09/23/2006 | A | Kansas State | 8 | W | 24 | 6 | 4-0 | 45,855 | Manhattan | Kan. | Bill Snyder Family Stadium | ||||
| 10/06/2006 | N | Middle Tennessee | 8 | W | 44 | 17 | 5-0 | 32,797 | Nashville | Tenn. | LP Field | ||||
| 10/14/2006 | H | Cincinnati | 7 | W | 23 | 17 | 6-0 | 1-0 | 41,549 | Louisville | Ky. | Papa John's Cardinal Stadium | |||
| 10/21/2006 | A | Syracuse | 6 | W | 28 | 13 | 7-0 | 2-0 | 35,708 | Syracuse | N.Y. | Carrier Dome | |||
| 11/02/2006 | H | 3 | West Virginia | 5 | W | 44 | 34 | 8-0 | 3-0 | 43,217 | Louisville | Ky. | Papa John's Cardinal Stadium | ||
| 11/09/2006 | A | 15 | Rutgers | 3 | L | 25 | 28 | 8-1 | 3-1 | 44,111 | Piscataway | N.J. | Rutgers Stadium | ||
| 11/18/2006 | H | South Florida | 10 | W | 31 | 8 | 9-1 | 4-1 | 40,348 | Louisville | Ky. | Papa John's Cardinal Stadium | |||
| 11/25/2006 | A | Pittsburgh | 8 | W | 48 | 24 | 10-1 | 5-1 | 41,881 | Pittsburgh | Pa. | Heinz Field | |||
| 12/02/2006 | H | Connecticut | 6 | W | 48 | 17 | 11-1 | 6-1 | 38,476 | Louisville | Ky. | Papa John's Cardinal Stadium | |||
| 01/02/2007 | N | 15 | Wake Forest | 5 | W | 24 | 13 | 12-1 | 6-1 | 74,470 | Miami | Fla. | Dolphin Stadium | Orange Bowl |