13 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 08/31/2024 | H | Austin Peay | W | 62 | 0 | 1-0 | 47,067 | Louisville | Ky. | L&N Federal Credit Union Stadium | |||||
| 09/07/2024 | H | Jacksonville State | 22 | W | 49 | 14 | 2-0 | 48,575 | Louisville | Ky. | L&N Federal Credit Union Stadium | ||||
| 09/21/2024 | H | Georgia Tech | 19 | W | 31 | 19 | 3-0 | 1-0 | 50,727 | Louisville | Ky. | L&N Federal Credit Union Stadium | |||
| 09/28/2024 | A | 16 | Notre Dame | 15 | L | 24 | 31 | 3-1 | 1-0 | 77,622 | South Bend | Ind. | Notre Dame Stadium | ||
| 10/05/2024 | H | Southern Methodist | 22 | L | 27 | 34 | 3-2 | 1-1 | 50,254 | Louisville | Ky. | L&N Federal Credit Union Stadium | |||
| 10/12/2024 | A | Virginia | W | 24 | 20 | 4-2 | 2-1 | 32,688 | Charlottesville | Va. | Scott Stadium | ||||
| 10/19/2024 | H | 6 | Miami, Fla. | L | 45 | 52 | 4-3 | 2-2 | 59,115 | Louisville | Ky. | L&N Federal Credit Union Stadium | |||
| 10/25/2024 | A | Boston College | W | 31 | 27 | 5-3 | 3-2 | 42,887 | Chestnut Hill | Mass. | Alumni Stadium | ||||
| 11/02/2024 | A | 11 | Clemson | W | 33 | 21 | 6-3 | 4-2 | 80,446 | Clemson | S.C. | Memorial Stadium | |||
| 11/16/2024 | A | Stanford | 22 | L | 35 | 38 | 6-4 | 4-3 | 18,685 | Stanford | Calif. | Stanford Stadium | |||
| 11/23/2024 | H | Pittsburgh | W | 37 | 9 | 7-4 | 5-3 | 49,441 | Louisville | Ky. | L&N Federal Credit Union Stadium | ||||
| 11/30/2024 | A | Kentucky | W | 41 | 14 | 8-4 | 5-3 | 58,612 | Lexington | Ky. | Kroger Field | ||||
| 12/31/2024 | N | Washington | W | 35 | 34 | 9-4 | 5-3 | 40,826 | El Paso | Texas | Sun Bowl Stadium | Sun Bowl |