26 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1950-12-02 | H | Kentucky Wesleyan | W | 81 | 53 | 1-0 | Louisville | KY | Jefferson County Armory | |||||
| 1950-12-06 | H | Georgetown College | W | 90 | 43 | 2-0 | Louisville | KY | Jefferson County Armory | |||||
| 1950-12-09 | H | Tampa | W | 87 | 74 | 3-0 | Louisville | KY | Jefferson County Armory | |||||
| 1950-12-11 | H | Mississippi State | W | 87 | 53 | 4-0 | Louisville | KY | Jefferson County Armory | |||||
| 1950-12-15 | A | Seton Hall | W | 60 | 58 | 5-0 | ||||||||
| 1950-12-16 | A | Villanova | L | 69 | 79 | 5-1 | ||||||||
| 1950-12-18 | H | Georgia Tech | W | 79 | 57 | 6-1 | Louisville | KY | Jefferson County Armory | |||||
| 1950-12-20 | H | William & Mary | W | 70 | 47 | 7-1 | Louisville | KY | Jefferson County Armory | |||||
| 1950-12-23 | H | Tennessee | W | 73 | 61 | 8-1 | Louisville | KY | Jefferson County Armory | |||||
| 1951-01-02 | A | Tampa | W | 89 | 74 | 9-1 | ||||||||
| 1951-01-05 | A | Miami, Fla. | W | 73 | 60 | 10-1 | ||||||||
| 1951-01-06 | A | Memphis | W | 51 | 48 | 11-1 | ||||||||
| 1951-01-10 | H | Xavier | W | 63 | 55 | 12-1 | Louisville | KY | Jefferson County Armory | |||||
| 1951-01-13 | H | Memphis | W | 67 | 58 | 13-1 | Louisville | KY | Jefferson County Armory | |||||
| 1951-01-17 | A | Dayton | L | 61 | 68 | 13-2 | ||||||||
| 1951-01-20 | H | Indiana Central | W | 96 | 61 | 14-2 | Louisville | KY | Jefferson County Armory | |||||
| 1951-01-25 | A | Kentucky Wesleyan | W | 69 | 52 | 15-2 | ||||||||
| 1951-01-31 | H | 8 | North Carolina State | W | 86 | 70 | 16-2 | Louisville | KY | Jefferson County Armory | ||||
| 1951-02-03 | H | Oklahoma City | W | 49 | 44 | 17-2 | Louisville | KY | Jefferson County Armory | |||||
| 1951-02-13 | A | 9 | North Carolina State | 14 | L | 78 | 92 | 17-3 | ||||||
| 1951-02-15 | H | Toledo | 14 | W | 67 | 58 | 18-3 | Louisville | KY | Jefferson County Armory | ||||
| 1951-02-17 | H | 17 | Dayton | 14 | L | 66 | 70 | 18-4 | Louisville | KY | Jefferson County Armory | |||
| 1951-02-19 | A | Xavier | L | 69 | 72 | 18-5 | ||||||||
| 1951-02-21 | H | Indiana State | W | 75 | 65 | 19-5 | Louisville | KY | Jefferson County Armory | |||||
| 1951-02-24 | A | Toledo | L | 66 | 72 | 19-6 | ||||||||
| 1951-03-20 | N | 1 | Kentucky | L | 68 | 79 | 19-7 | Raleigh | NC | Reynolds Coliseum | 1951 NCAA Tournament East Regional First Round |