11 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/12/2020 | H | Western Kentucky | W | 35 | 21 | 1-0 | 11,179 | Louisville | Ky. | Cardinal Stadium | |||||
| 09/19/2020 | H | 17 | Miami, Fla. | 18 | L | 34 | 47 | 1-1 | 0-1 | 12,120 | Louisville | Ky. | Cardinal Stadium | ||
| 09/26/2020 | A | 21 | Pittsburgh | 24 | L | 20 | 23 | 1-2 | 0-2 | 0 | Pittsburgh | Pa. | Heinz Field | ||
| 10/09/2020 | A | Georgia Tech | L | 27 | 46 | 1-3 | 0-3 | 11,000 | Atlanta | Ga. | Bobby Dodd Stadium | ||||
| 10/17/2020 | A | 4 | Notre Dame | L | 7 | 12 | 1-4 | 0-4 | 10,182 | South Bend | Ind. | Notre Dame Stadium | |||
| 10/24/2020 | H | Florida State | W | 48 | 16 | 2-4 | 1-4 | 11,465 | Louisville | Ky. | Cardinal Stadium | ||||
| 10/31/2020 | H | Virginia Tech | L | 35 | 42 | 2-5 | 1-5 | 11,901 | Louisville | Ky. | Cardinal Stadium | ||||
| 11/14/2020 | A | Virginia | L | 17 | 31 | 2-6 | 1-6 | 1,000 | Charlottesville | Va. | Scott Stadium | ||||
| 11/20/2020 | H | Syracuse | W | 30 | 0 | 3-6 | 2-6 | 11,192 | Louisville | Ky. | Cardinal Stadium | ||||
| 11/28/2020 | A | Boston College | L | 27 | 34 | 3-7 | 2-7 | 0 | Chestnut Hill | Mass. | Alumni Stadium | ||||
| 12/12/2020 | H | Wake Forest | W | 45 | 21 | 4-7 | 3-7 | 10,959 | Louisville | Ky. | Cardinal Stadium |