Series record: 11-7 (Home: 9-0, Away: 1-7, Neutral: 1-0)
18 games
| Date | Site | Opp AP | UL AP | W/L | UL | Opp | OT | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 12/18/1973 | A | 8 | W | 74 | 70 | 9,100 | Clemson | S.C. | Littlejohn Coliseum | |||
| 12/18/1974 | H | 4 | W | 90 | 75 | 14,038 | Louisville | Ky. | Freedom Hall | |||
| 03/20/2006 | H | W | 74 | 68 | 12,344 | Louisville | Ky. | Freedom Hall | 2006 NIT Second Round | |||
| 01/07/2015 | H | 5 | W | 58 | 52 | 21,676 | Louisville | Ky. | KFC Yum! Center | |||
| 01/10/2016 | A | 16 | L | 62 | 66 | 9,562 | Greenville | S.C. | Bon Secours Wellness Arena | |||
| 01/19/2017 | H | 12 | W | 92 | 60 | 21,436 | Louisville | Ky. | KFC Yum! Center | |||
| 01/06/2018 | A | 25 | L | 69 | 74 | OT | 7,594 | Clemson | S.C. | Littlejohn Coliseum | ||
| 02/16/2019 | H | 16 | W | 56 | 55 | 16,043 | Louisville | Ky. | KFC Yum! Center | |||
| 01/25/2020 | H | 6 | W | 80 | 62 | 17,654 | Louisville | Ky. | KFC Yum! Center | |||
| 02/15/2020 | A | 5 | L | 62 | 77 | 9,146 | Clemson | S.C. | Littlejohn Coliseum | |||
| 01/27/2021 | A | 25 | L | 50 | 54 | 1,876 | Clemson | S.C. | Littlejohn Coliseum | |||
| 02/19/2022 | H | W | 70 | 61 | 13,242 | Louisville | Ky. | KFC Yum! Center | ||||
| 01/11/2023 | A | L | 70 | 83 | 7,789 | Clemson | S.C. | Littlejohn Coliseum | ||||
| 02/18/2023 | H | W | 83 | 73 | 15,157 | Louisville | Ky. | KFC Yum! Center | ||||
| 01/30/2024 | A | L | 64 | 70 | 6,760 | Clemson | S.C. | Littlejohn Coliseum | ||||
| 01/07/2025 | H | W | 74 | 64 | 14,991 | Louisville | Ky. | KFC Yum! Center | ||||
| 03/14/2025 | N | 10 | 13 | W | 76 | 73 | 18,116 | Charlotte | N.C. | Spectrum Center | 2025 ACC Men's Basketball Tournament Semifinals | |
| 02/28/2026 | A | 24 | L | 75 | 80 | 8,084 | Clemson | S.C. | Littlejohn Coliseum |