30 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1977-11-30 | A | Providence | 9 | L | 51 | 57 | 0-1 | 0-0 | 11,134 | Providence | RI | Providence Civic Center | ||
| 1977-12-03 | H | Vanderbilt | 9 | W | 96 | 66 | 1-1 | 0-0 | 16,433 | Louisville | KY | Freedom Hall | ||
| 1977-12-07 | A | 9 | Michigan | 16 | W | 88 | 85 | 2-1 | 0-0 | 13,609 | Ann Arbor | MI | Crisler Arena | |
| 1977-12-10 | H | Robert Morris | 16 | W | 104 | 68 | 3-1 | 0-0 | 11,995 | Louisville | KY | Freedom Hall | ||
| 1977-12-13 | H | 17 | Purdue | 10 | W | 68 | 66 | 4-1 | 0-0 | 16,433 | Louisville | KY | Freedom Hall | |
| 1977-12-19 | H | Dayton | 8 | W | 69 | 63 | 5-1 | 0-0 | 14,191 | Louisville | KY | Freedom Hall | ||
| 1977-12-22 | H | 2 | Marquette | 8 | W | 61 | 60 | 6-1 | 0-0 | 16,433 | Louisville | KY | Freedom Hall | |
| 1977-12-28 | H | La Salle | 7 | W | 113 | 85 | 7-1 | 0-0 | 9,474 | Louisville | KY | Freedom Hall | 1977 Louisville Holiday Classic | |
| 1977-12-29 | H | Georgia | 7 | L | 70 | 73 | 7-2 | 0-0 | 11,079 | Louisville | KY | Freedom Hall | 1977 Louisville Holiday Classic | |
| 1978-01-03 | A | Memphis | 10 | W | 78 | 75 | 8-2 | 1-0 | 11,200 | Memphis | TN | Mid-South Coliseum | ||
| 1978-01-07 | A | 12 | Cincinnati | 10 | W | 78 | 75 | 9-2 | 2-0 | 17,038 | Cincinnati | OH | Riverfront Coliseum | |
| 1978-01-14 | H | Georgia Tech | 9 | W | 90 | 84 | 10-2 | 3-0 | 16,501 | Louisville | KY | Freedom Hall | ||
| 1978-01-18 | H | Louisiana-Lafayette | 9 | W | 78 | 75 | 11-2 | 3-0 | 7,589 | Louisville | KY | Freedom Hall | ||
| 1978-01-22 | H | Florida State | 9 | L | 66 | 70 | 11-3 | 3-1 | 14,954 | Louisville | KY | Freedom Hall | ||
| 1978-01-26 | A | Tulane | 12 | W | 105 | 82 | 12-3 | 4-1 | 3,200 | New Orleans | LA | Louisiana Superdome | ||
| 1978-02-01 | A | Marshall | 9 | W | 85 | 69 | 13-3 | 4-1 | 6,534 | Huntington | WV | Memorial Field House | ||
| 1978-02-04 | H | Cincinnati | 9 | W | 83 | 76 | 14-3 | 5-1 | 12,942 | Louisville | KY | Freedom Hall | ||
| 1978-02-07 | H | Tulane | 9 | W | 115 | 86 | 15-3 | 6-1 | 9,473 | Louisville | KY | Freedom Hall | ||
| 1978-02-11 | A | Saint Louis | 9 | W | 63 | 61 | 16-3 | 7-1 | 6,782 | St. Louis | MO | Kiel Auditorium | ||
| 1978-02-14 | A | Georgia Tech | 9 | L | 59 | 69 | 16-4 | 7-2 | 5,681 | Atlanta | GA | Alexander Coliseum | ||
| 1978-02-17 | A | 14 | Florida State | 9 | L | 70 | 81 | 16-5 | 7-3 | 4,296 | Tallahassee | FL | Tully Gymnasium | |
| 1978-02-19 | A | Minnesota | 9 | L | 71 | 72 | 16-6 | 7-3 | 15,863 | Minneapolis | MN | Williams Arena | ||
| 1978-02-23 | H | Ball State | 20 | W | 104 | 84 | 17-6 | 7-3 | 8,402 | Louisville | KY | Freedom Hall | ||
| 1978-02-25 | H | Memphis | 20 | W | 115 | 97 | 18-6 | 8-3 | 10,635 | Louisville | KY | Freedom Hall | ||
| 1978-02-27 | H | Saint Louis | 20 | W | 94 | 59 | 19-6 | 9-3 | 10,270 | Louisville | KY | Freedom Hall | ||
| 1978-03-02 | N | Tulane | 20 | W | 93 | 64 | 20-6 | 9-3 | 10,081 | Cincinnati | OH | Riverfront Coliseum | 1978 Metro Tournament Quarterfinal | |
| 1978-03-03 | N | Memphis | 20 | W | 67 | 62 | 21-6 | 9-3 | 10,618 | Cincinnati | OH | Riverfront Coliseum | 1978 Metro Tournament Semifinal | |
| 1978-03-04 | N | 11 | Florida State | 20 | W | 94 | 93 | 22-6 | 9-3 | 10,627 | Cincinnati | OH | Riverfront Coliseum | 1978 Metro Tournament Final |
| 1978-03-12 | N | St. John's | 12 | W | 76 | 68 | 23-6 | 9-3 | 10,075 | Tulsa | OK | Mabee Center | 1978 NCAA Tournament Midwest Regional First Round | |
| 1978-03-17 | N | 3 | DePaul | 9 | L | 89 | 90 | 23-7 | 9-3 | 10,300 | Lawrence | KS | Allen Fieldhouse | 1978 NCAA Tournament Midwest Regional Semifinal |