39 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 11/22/1985 | N | Miami, Ohio | 9 | W | 81 | 65 | 1-0 | 0-0 | 10,416 | Cincinnati | Ohio | Riverfront Coliseum | 1985 Big Apple NIT | ||
| 11/24/1985 | N | Tulsa | 9 | W | 80 | 74 | 2-0 | 0-0 | 6,720 | Cincinnati | Ohio | Riverfront Coliseum | 1985 Big Apple NIT | ||
| 11/29/1985 | N | 5 | Kansas | 9 | L | 78 | 83 | 2-1 | 0-0 | 14,225 | New York | N.Y. | Madison Square Garden IV | 1985 Big Apple NIT | |
| 12/01/1985 | N | 18 | St. John's | 9 | L | 79 | 86 | 2-2 | 0-0 | 8,598 | New York | N.Y. | Madison Square Garden IV | 1985 Big Apple NIT | |
| 12/07/1985 | H | Purdue | 16 | W | 77 | 58 | 3-2 | 0-0 | 19,265 | Louisville | Ky. | Freedom Hall | |||
| 12/10/1985 | H | Iona | 15 | W | 88 | 75 | 4-2 | 0-0 | 19,038 | Louisville | Ky. | Freedom Hall | |||
| 12/14/1985 | H | Western Kentucky | 15 | W | 73 | 70 | 5-2 | 0-0 | 19,308 | Louisville | Ky. | Freedom Hall | |||
| 12/18/1985 | H | 17 | Indiana | 16 | W | 65 | 63 | 6-2 | 0-0 | 19,493 | Louisville | Ky. | Freedom Hall | ||
| 12/28/1985 | A | 13 | Kentucky | 15 | L | 64 | 69 | 6-3 | 0-0 | 24,180 | Lexington | Ky. | Rupp Arena | ||
| 01/04/1986 | H | Wyoming | 18 | W | 94 | 62 | 7-3 | 0-0 | 19,037 | Louisville | Ky. | Freedom Hall | |||
| 01/06/1986 | H | Eastern Kentucky | 17 | W | 86 | 55 | 8-3 | 0-0 | 19,235 | Louisville | Ky. | Freedom Hall | |||
| 01/09/1986 | A | 6 | Memphis | 17 | L | 71 | 73 | 8-4 | 0-1 | 11,200 | Memphis | Tenn. | Mid-South Coliseum | ||
| 01/13/1986 | A | Southern Mississippi | 18 | W | 59 | 54 | 9-4 | 1-1 | 8,053 | Hattiesburg | Miss. | Reed Green Coliseum | |||
| 01/15/1986 | A | Florida State | 18 | W | 85 | 64 | 10-4 | 2-1 | 7,198 | Tallahassee | Fla. | Tallahassee-Leon County Civic Center | |||
| 01/18/1986 | H | 4 | Syracuse | 18 | W | 83 | 73 | 11-4 | 2-1 | 19,318 | Louisville | Ky. | Freedom Hall | ||
| 01/20/1986 | H | Cincinnati | 13 | L | 82 | 84 | 11-5 | 2-2 | 19,304 | Louisville | Ky. | Freedom Hall | |||
| 01/25/1986 | A | 7 | Kansas | 13 | L | 69 | 71 | 11-6 | 2-2 | 15,000 | Lawrence | Kan. | Allen Fieldhouse | ||
| 01/28/1986 | H | La Salle | 18 | W | 72 | 60 | 12-6 | 2-2 | 18,908 | Louisville | Ky. | Freedom Hall | |||
| 02/01/1986 | H | UCLA | 18 | W | 91 | 72 | 13-6 | 2-2 | 19,384 | Louisville | Ky. | Freedom Hall | |||
| 02/03/1986 | H | South Carolina | 16 | W | 74 | 72 | 14-6 | 3-2 | 18,981 | Louisville | Ky. | Freedom Hall | |||
| 02/06/1986 | H | 15 | Virginia Tech | 16 | W | 103 | 68 | 15-6 | 4-2 | 19,406 | Louisville | Ky. | Freedom Hall | ||
| 02/08/1986 | A | North Carolina State | 16 | L | 64 | 76 | 15-7 | 4-2 | 12,400 | Raleigh | N.C. | Reynolds Coliseum | |||
| 02/10/1986 | A | 20 | Virginia Tech | 19 | W | 93 | 83 | 16-7 | 5-2 | 10,000 | Blacksburg | Va. | Cassell Coliseum | ||
| 02/13/1986 | A | Cincinnati | 19 | W | 74 | 58 | 17-7 | 6-2 | 12,683 | Cincinnati | Ohio | Riverfront Coliseum | |||
| 02/15/1986 | A | DePaul | 19 | W | 72 | 53 | 18-7 | 6-2 | 15,754 | Rosemont | Ill. | Rosemont Horizon | |||
| 02/17/1986 | H | Southern Mississippi | 16 | W | 83 | 74 | 19-7 | 7-2 | 19,240 | Louisville | Ky. | Freedom Hall | |||
| 02/19/1986 | H | Florida State | 16 | W | 89 | 67 | 20-7 | 8-2 | 19,157 | Louisville | Ky. | Freedom Hall | |||
| 02/22/1986 | A | Houston | 16 | W | 76 | 59 | 21-7 | 8-2 | 5,125 | Houston | Texas | Hofheinz Pavilion | |||
| 02/24/1986 | H | South Alabama | 13 | W | 66 | 55 | 22-7 | 8-2 | 19,063 | Louisville | Ky. | Freedom Hall | |||
| 02/26/1986 | A | South Carolina | 13 | W | 65 | 63 | 23-7 | 9-2 | 6,071 | Columbia | S.C. | Carolina Coliseum | |||
| 03/02/1986 | H | 7 | Memphis | 13 | W | 70 | 69 | 24-7 | 10-2 | 19,582 | Louisville | Ky. | Freedom Hall | ||
| 03/08/1986 | H | Cincinnati | 11 | W | 86 | 65 | 25-7 | 10-2 | 19,452 | Louisville | Ky. | Freedom Hall | 1986 Metro Tournament Semifinal | ||
| 03/09/1986 | H | 10 | Memphis | 11 | W | 88 | 79 | 26-7 | 10-2 | 19,611 | Louisville | Ky. | Freedom Hall | 1986 Metro Tournament Final | |
| 03/13/1986 | N | Drexel | 7 | W | 93 | 73 | 27-7 | 10-2 | 9,037 | Ogden | Utah | Dee Events Center | 1986 NCAA Tournament West Regional First Round | ||
| 03/15/1986 | N | 14 | Bradley | 7 | W | 82 | 68 | 28-7 | 10-2 | 10,061 | Ogden | Utah | Dee Events Center | 1986 NCAA Tournament West Regional Second Round | |
| 03/20/1986 | N | 8 | North Carolina | 7 | W | 94 | 79 | 29-7 | 10-2 | 10,936 | Houston | Texas | The Summit | 1986 NCAA Tournament West Regional Semifinal | |
| 03/22/1986 | N | Auburn | 7 | W | 84 | 76 | 30-7 | 10-2 | 9,650 | Houston | Texas | The Summit | 1986 NCAA Tournament West Regional Final | ||
| 03/29/1986 | N | Louisiana State | 7 | W | 88 | 77 | 31-7 | 10-2 | 16,493 | Dallas | Texas | Reunion Arena | 1986 NCAA Tournament Semifinal | ||
| 03/31/1986 | N | 1 | Duke | 7 | W | 72 | 69 | 32-7 | 10-2 | 16,493 | Dallas | Texas | Reunion Arena | 1986 NCAA Tournament Final |