33 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 11/18/1988 | A | Xavier | 4 | L | 83 | 85 | 0-1 | 0-0 | 16,574 | Cincinnati | Ohio | Riverfront Coliseum | 1988 Big Apple NIT | ||
| 11/30/1988 | A | Vanderbilt | 13 | L | 62 | 65 | 0-2 | 0-0 | 15,263 | Nashville | Tenn. | Memorial Gymnasium | |||
| 12/03/1988 | N | Indiana | 13 | W | 101 | 79 | 1-2 | 0-0 | 45,214 | Indianapolis | Ind. | Hoosier Dome | 1988 Bank One Big Four Classic | ||
| 12/06/1988 | H | Murray State | 15 | W | 83 | 51 | 2-2 | 0-0 | 19,382 | Louisville | Ky. | Freedom Hall | |||
| 12/08/1988 | A | Western Kentucky | 15 | W | 81 | 69 | 3-2 | 0-0 | 13,000 | Bowling Green | Ky. | Diddle Arena | |||
| 12/10/1988 | H | Dayton | 15 | W | 95 | 68 | 4-2 | 0-0 | 19,364 | Louisville | Ky. | Freedom Hall | |||
| 12/17/1988 | H | Oklahoma State | 15 | W | 92 | 90 | 5-2 | 0-0 | 19,314 | Louisville | Ky. | Freedom Hall | |||
| 12/21/1988 | H | Eastern Kentucky | 14 | W | 76 | 40 | 6-2 | 0-0 | 19,139 | Louisville | Ky. | Freedom Hall | |||
| 12/31/1988 | H | Kentucky | 14 | W | 97 | 75 | 7-2 | 0-0 | 19,502 | Louisville | Ky. | Freedom Hall | |||
| 01/04/1989 | H | Virginia | 13 | W | 74 | 71 | 8-2 | 0-0 | 19,272 | Louisville | Ky. | Freedom Hall | |||
| 01/07/1989 | H | DePaul | 13 | W | 81 | 67 | 9-2 | 0-0 | 19,437 | Louisville | Ky. | Freedom Hall | |||
| 01/09/1989 | A | Virginia Tech | 9 | W | 82 | 73 | 10-2 | 1-0 | 9,971 | Blacksburg | Va. | Cassell Coliseum | |||
| 01/11/1989 | H | South Carolina | 9 | W | 75 | 52 | 11-2 | 2-0 | 19,426 | Louisville | Ky. | Freedom Hall | |||
| 01/15/1989 | A | 19 | Georgia Tech | 9 | W | 67 | 65 | 12-2 | 2-0 | 9,111 | Atlanta | Ga. | Alexander Coliseum | ||
| 01/22/1989 | H | 10 | Nevada-Las Vegas | 4 | W | 92 | 74 | 13-2 | 2-0 | 19,632 | Louisville | Ky. | Freedom Hall | ||
| 01/26/1989 | A | Southern Mississippi | 3 | W | 95 | 76 | 14-2 | 3-0 | 8,095 | Hattiesburg | Miss. | Reed Green Coliseum | |||
| 01/29/1989 | H | 17 | Ohio State | 3 | L | 79 | 85 | 14-3 | 3-0 | 19,602 | Louisville | Ky. | Freedom Hall | ||
| 02/01/1989 | H | Virginia Tech | 7 | W | 108 | 95 | 15-3 | 4-0 | 19,497 | Louisville | Ky. | Freedom Hall | |||
| 02/04/1989 | A | Memphis | 7 | W | 101 | 85 | 16-3 | 5-0 | 11,200 | Memphis | Tenn. | Mid-South Coliseum | |||
| 02/06/1989 | H | 12 | Florida State | 4 | L | 78 | 81 | 16-4 | 5-1 | 19,345 | Louisville | Ky. | Freedom Hall | ||
| 02/08/1989 | A | Cincinnati | 4 | W | 69 | 66 | 17-4 | 6-1 | 8,706 | Cincinnati | Ohio | Cincinnati Gardens | |||
| 02/12/1989 | A | UCLA | 4 | L | 75 | 77 | 17-5 | 6-1 | 12,547 | Los Angeles | Calif. | Pauley Pavilion | |||
| 02/16/1989 | A | 7 | Florida State | 10 | W | 78 | 77 | OT | 18-5 | 7-1 | 13,339 | Tallahassee | Fla. | Tallahassee-Leon County Civic Center | |
| 02/20/1989 | H | Memphis | 8 | L | 67 | 72 | 18-6 | 7-2 | 19,267 | Louisville | Ky. | Freedom Hall | |||
| 02/22/1989 | H | Southern Mississippi | 8 | W | 96 | 83 | 19-6 | 8-2 | 19,263 | Louisville | Ky. | Freedom Hall | |||
| 02/25/1989 | A | South Carolina | 8 | L | 73 | 77 | 19-7 | 8-3 | 12,051 | Columbia | S.C. | Carolina Coliseum | |||
| 03/01/1989 | H | Cincinnati | 14 | L | 71 | 77 | 19-8 | 8-4 | 19,434 | Louisville | Ky. | Freedom Hall | |||
| 03/04/1989 | A | Notre Dame | 14 | W | 87 | 77 | 20-8 | 8-4 | 11,418 | South Bend | Ind. | Joyce Athletic and Convocation Center | |||
| 03/11/1989 | N | Memphis | 16 | W | 71 | 70 | 21-8 | 8-4 | 10,433 | Columbia | S.C. | Carolina Coliseum | 1989 Metro Tournament Semifinal | ||
| 03/12/1989 | N | 14 | Florida State | 16 | W | 87 | 80 | 22-8 | 8-4 | 7,052 | Columbia | S.C. | Carolina Coliseum | 1989 Metro Tournament Final | |
| 03/16/1989 | N | Arkansas-Little Rock | 12 | W | 76 | 71 | 23-8 | 8-4 | 37,232 | Indianapolis | Ind. | Hoosier Dome | 1989 NCAA Tournament Midwest Regional First Round | ||
| 03/18/1989 | N | Arkansas | 12 | W | 93 | 84 | 24-8 | 8-4 | 37,444 | Indianapolis | Ind. | Hoosier Dome | 1989 NCAA Tournament Midwest Regional Second Round | ||
| 03/24/1989 | N | 3 | Illinois | 12 | L | 69 | 83 | 24-9 | 8-4 | 33,560 | Minneapolis | Minn. | Metrodome | 1989 NCAA Tournament Midwest Regional Semifinal |