Series record: 28-19 (Home: 16-5, Away: 7-11, Neutral: 5-3)
47 games
| Date | Site | Opp AP | UL AP | W/L | UL | Opp | OT | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 01/05/1952 | H | 14 | W | 65 | 59 | Louisville | Ky. | |||||
| 02/11/1953 | A | 17 | L | 62 | 73 | |||||||
| 01/06/1954 | A | L | 53 | 72 | ||||||||
| 01/03/1955 | H | 16 | W | 73 | 69 | Louisville | Ky. | |||||
| 01/11/1956 | A | 13 | W | 80 | 75 | OT | South Bend | Ind. | Notre Dame Fieldhouse | |||
| 12/22/1956 | H | 6 | W | 85 | 75 | 10,740 | Louisville | Ky. | Freedom Hall | |||
| 01/18/1958 | H | W | 94 | 83 | 8,200 | Louisville | Ky. | Freedom Hall | ||||
| 01/29/1958 | A | L | 53 | 73 | 3,800 | Notre Dame | Ind. | |||||
| 12/20/1958 | H | L | 53 | 61 | 6,000 | Louisville | Ky. | Freedom Hall | 1958 Bluegrass Invitational | |||
| 02/27/1960 | N | L | 54 | 65 | Chicago | Ill. | Chicago Stadium | |||||
| 03/20/1973 | N | L | 71 | 79 | 9,388 | New York | N.Y. | Madison Square Garden IV | 1973 NIT | |||
| 12/05/1987 | N | 14 | L | 54 | 69 | 43,601 | Indianapolis | Ind. | Hoosier Dome | 1987 Bank One Big Four Classic | ||
| 03/04/1989 | A | 14 | W | 87 | 77 | 11,418 | South Bend | Ind. | Joyce Athletic and Convocation Center | |||
| 12/02/1989 | N | 19 | 13 | W | 84 | 73 | 40,128 | Indianapolis | Ind. | Hoosier Dome | 1989 Big Four Classic | |
| 03/02/1991 | H | W | 65 | 59 | 19,161 | Louisville | Ky. | Freedom Hall | ||||
| 12/05/1991 | A | W | 84 | 81 | 8,467 | South Bend | Ind. | Joyce Athletic and Convocation Center | ||||
| 03/07/1993 | H | 22 | W | 83 | 68 | 19,687 | Louisville | Ky. | Freedom Hall | |||
| 02/26/1994 | A | 13 | W | 85 | 82 | OT | 11,418 | South Bend | Ind. | Joyce Athletic and Convocation Center | ||
| 01/07/1995 | H | W | 80 | 72 | 19,522 | Louisville | Ky. | Freedom Hall | ||||
| 02/04/2006 | H | W | 89 | 86 | OT | 19,327 | Louisville | Ky. | Freedom Hall | |||
| 01/03/2007 | A | 17 | L | 62 | 78 | 8,580 | South Bend | Ind. | Joyce Athletic and Convocation Center | |||
| 02/28/2008 | H | 17 | 13 | W | 90 | 85 | 19,881 | Louisville | Ky. | Freedom Hall | ||
| 01/12/2009 | H | 12 | 20 | W | 87 | 73 | OT | 19,865 | Louisville | Ky. | Freedom Hall | |
| 02/12/2009 | A | 5 | L | 57 | 90 | 11,418 | South Bend | Ind. | Joyce Athletic and Convocation Center | |||
| 02/17/2010 | H | W | 91 | 89 | 2OT | 19,623 | Louisville | Ky. | Freedom Hall | |||
| 02/09/2011 | A | 8 | 16 | L | 79 | 89 | OT | 8,659 | South Bend | Ind. | Purcell Pavillion at Joyce Center | |
| 03/11/2011 | N | 4 | 14 | W | 83 | 77 | OT | 19,375 | New York | N.Y. | Madison Square Garden IV | 2011 Big East Tournament Semifinal |
| 01/07/2012 | H | 11 | L | 65 | 67 | 2OT | 22,687 | Louisville | Ky. | KFC Yum! Center | ||
| 03/09/2012 | N | 23 | W | 64 | 50 | 20,057 | New York | N.Y. | Madison Square Garden IV | 2012 Big East Tournament Semifinal | ||
| 02/09/2013 | A | 25 | 11 | L | 101 | 104 | 5OT | 9,149 | South Bend | Ind. | Purcell Pavillion at Joyce Center | |
| 03/09/2013 | H | 24 | 8 | W | 73 | 57 | 22,815 | Louisville | Ky. | KFC Yum! Center | ||
| 03/15/2013 | N | 24 | 4 | W | 69 | 57 | 20,057 | New York | N.Y. | Madison Square Garden IV | 2013 Big East Tournament Semifinal | |
| 03/04/2015 | H | 12 | 16 | L | 59 | 71 | 21,024 | Louisville | Ky. | KFC Yum! Center | ||
| 02/13/2016 | A | 13 | L | 66 | 71 | 9,149 | South Bend | Ind. | Joyce Athletic and Convocation Center | |||
| 01/04/2017 | A | 23 | 9 | L | 70 | 77 | 8,420 | South Bend | Ind. | Purcell Pavillion at Joyce Center | ||
| 03/04/2017 | H | 19 | 8 | W | 71 | 64 | 22,612 | Louisville | Ky. | KFC Yum! Center | ||
| 01/16/2018 | A | W | 82 | 78 | 2OT | 9,076 | South Bend | Ind. | Joyce Athletic and Convocation Center | |||
| 03/03/2019 | H | W | 75 | 61 | 16,911 | Louisville | Ky. | KFC Yum! Center | ||||
| 03/13/2019 | N | W | 75 | 53 | 20,116 | Charlotte | N.C. | Spectrum Center | 2019 ACC Tournament Second Round | |||
| 01/11/2020 | A | 13 | W | 67 | 64 | 8,404 | South Bend | Ind. | Joyce Athletic and Convocation Center | |||
| 02/23/2021 | H | W | 69 | 57 | 2,948 | Louisville | Ky. | KFC Yum! Center | ||||
| 01/22/2022 | H | L | 70 | 82 | 16,175 | Louisville | Ky. | KFC Yum! Center | ||||
| 02/09/2022 | A | L | 57 | 63 | 8,260 | South Bend | Ind. | Purcell Pavillion at Joyce Center | ||||
| 01/28/2023 | A | L | 62 | 76 | 6,531 | South Bend | Ind. | Joyce Athletic and Convocation Center | ||||
| 02/21/2024 | H | L | 50 | 72 | 11,342 | Louisville | Ky. | KFC Yum! Center | ||||
| 02/16/2025 | A | W | 75 | 60 | 5,437 | South Bend | Ind. | Joyce Athletic and Convocation Center | ||||
| 02/04/2026 | H | 24 | W | 76 | 65 | 14,787 | Louisville | Ky. | KFC Yum! Center |