30 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1990-12-01 | N | 10 | Indiana | 25 | L | 52 | 72 | 0-1 | 0-0 | 38,043 | Indianapolis | IN | Hoosier Dome | 1990 Bank One Big Four Classic |
| 1990-12-12 | H | DePaul | W | 94 | 75 | 1-1 | 0-0 | 19,008 | Louisville | KY | Freedom Hall | |||
| 1990-12-15 | H | Prairie View A&M | W | 100 | 76 | 2-1 | 0-0 | 18,122 | Louisville | KY | Freedom Hall | |||
| 1990-12-17 | A | Western Kentucky | W | 86 | 79 | 3-1 | 0-0 | 10,000 | Bowling Green | KY | Diddle Arena | |||
| 1990-12-19 | H | Cleveland State | W | 95 | 80 | 4-1 | 0-0 | 19,319 | Louisville | KY | Freedom Hall | |||
| 1990-12-22 | A | George Mason | W | 85 | 80 | 5-1 | 0-0 | 4,878 | Fairfax | VA | Patriot Center | |||
| 1990-12-29 | H | 18 | Kentucky | L | 85 | 93 | 5-2 | 0-0 | 19,589 | Louisville | KY | Freedom Hall | ||
| 1991-01-03 | A | Cincinnati | L | 64 | 72 | 5-3 | 0-1 | 13,176 | Cincinnati | OH | Shoemaker Center | |||
| 1991-01-05 | A | 10 | UCLA | L | 81 | 88 | 5-4 | 0-1 | 12,313 | Los Angeles | CA | Pauley Pavilion | ||
| 1991-01-07 | H | 21 | South Carolina | L | 64 | 67 | 5-5 | 0-2 | 19,320 | Louisville | KY | Freedom Hall | ||
| 1991-01-10 | H | Memphis | L | 56 | 65 | 5-6 | 0-3 | 19,145 | Louisville | KY | Freedom Hall | |||
| 1991-01-12 | A | Florida State | L | 66 | 77 | 5-7 | 0-4 | 9,545 | Tallahassee | FL | Tallahassee-Leon County Civic Center | |||
| 1991-01-14 | A | Tulane | W | 79 | 73 | 6-7 | 1-4 | 3,647 | New Orleans | LA | Fogelman Arena | |||
| 1991-01-19 | H | South Alabama | W | 85 | 83 | 7-7 | 1-4 | 19,346 | Louisville | KY | Freedom Hall | |||
| 1991-01-24 | H | 15 | Southern Mississippi | L | 81 | 84 | 7-8 | 1-5 | 19,363 | Louisville | KY | Freedom Hall | ||
| 1991-01-26 | H | 1 | Nevada-Las Vegas | L | 85 | 97 | 7-9 | 1-5 | 19,465 | Louisville | KY | Freedom Hall | ||
| 1991-01-30 | H | Virginia Tech | L | 79 | 86 | 7-10 | 1-6 | 18,783 | Louisville | KY | Freedom Hall | |||
| 1991-02-02 | A | 17 | Southern Mississippi | L | 66 | 77 | 7-11 | 1-7 | 8,095 | Hattiesburg | MS | Reed Green Coliseum | ||
| 1991-02-06 | A | South Carolina | L | 67 | 70 | 7-12 | 1-8 | 11,239 | Columbia | SC | Carolina Coliseum | |||
| 1991-02-09 | H | Florida State | W | 88 | 72 | 8-12 | 2-8 | 19,115 | Louisville | KY | Freedom Hall | |||
| 1991-02-13 | A | Virginia Tech | L | 56 | 72 | 8-13 | 2-9 | 5,418 | Blacksburg | VA | Cassell Coliseum | |||
| 1991-02-16 | A | Memphis | L | 73 | 91 | 8-14 | 2-10 | 11,200 | Memphis | TN | Mid-South Coliseum | |||
| 1991-02-20 | H | Louisiana-Lafayette | W | 104 | 77 | 9-14 | 2-10 | 18,356 | Louisville | KY | Freedom Hall | |||
| 1991-02-24 | A | Georgia Tech | L | 69 | 82 | 9-15 | 2-10 | 9,526 | Atlanta | GA | Alexander Coliseum | |||
| 1991-02-26 | H | Tulane | W | 95 | 72 | 10-15 | 3-10 | 19,159 | Louisville | KY | Freedom Hall | |||
| 1991-02-28 | H | Cincinnati | W | 68 | 61 | 11-15 | 4-10 | 19,258 | Louisville | KY | Freedom Hall | |||
| 1991-03-02 | H | Notre Dame | W | 65 | 59 | 12-15 | 4-10 | 19,161 | Louisville | KY | Freedom Hall | |||
| 1991-03-07 | N | 22 | Southern Mississippi | W | 83 | 76 | 13-15 | 4-10 | 6,245 | Roanoke | VA | Roanoke Civic Center | 1991 Metro Tournament Quarterfinal | |
| 1991-03-08 | N | Memphis | W | 72 | 70 | 14-15 | 4-10 | 7,569 | Roanoke | VA | Roanoke Civic Center | 1991 Metro Tournament Semifinal | ||
| 1991-03-09 | N | Florida State | L | 69 | 76 | 14-16 | 4-10 | 7,244 | Roanoke | VA | Roanoke Civic Center | 1991 Metro Tournament Final |