12 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/05/2004 | H | Kentucky | RV | W | 28 | 0 | 1-0 | 42,681 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 09/11/2004 | A | Army | RV | W | 52 | 21 | 2-0 | 1-0 | 28,130 | West Point | N.Y. | Michie Stadium | |||
| 09/25/2004 | A | North Carolina | 24 | W | 34 | 0 | 3-0 | 1-0 | 49,000 | Chapel Hill | N.C. | Kenan Stadium | |||
| 10/02/2004 | H | East Carolina | 22 | W | 59 | 7 | 4-0 | 2-0 | 40,220 | Louisville | Ky. | Papa John's Cardinal Stadium | |||
| 10/14/2004 | A | 3 | Miami, Fla. | 18 | L | 38 | 41 | 4-1 | 2-0 | 63,715 | Miami | Fla. | Orange Bowl | ||
| 10/22/2004 | H | South Florida | 15 | W | 41 | 9 | 5-1 | 3-0 | 42,032 | Louisville | Ky. | Papa John's Cardinal Stadium | |||
| 11/04/2004 | A | Memphis | 14 | W | 56 | 49 | 6-1 | 4-0 | 52,384 | Memphis | Tenn. | Liberty Bowl Memorial Stadium | |||
| 11/10/2004 | H | Texas Christian | 12 | W | 55 | 28 | 7-1 | 5-0 | 40,107 | Louisville | Ky. | Papa John's Cardinal Stadium | |||
| 11/20/2004 | A | Houston | 8 | W | 65 | 27 | 8-1 | 6-0 | 20,176 | Houston | Texas | Robertson Stadium | |||
| 11/27/2004 | H | Cincinnati | 7 | W | 70 | 7 | 9-1 | 7-0 | 37,617 | Louisville | Ky. | Papa John's Cardinal Stadium | |||
| 12/04/2004 | A | Tulane | 7 | W | 55 | 7 | 10-1 | 8-0 | 22,169 | New Orleans | La. | Superdome | |||
| 12/31/2004 | N | 10 | Boise State | 7 | W | 44 | 40 | 11-1 | 8-0 | 58,355 | Memphis | Tenn. | Liberty Bowl Memorial Stadium | Liberty Bowl |