12 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 08/30/2007 | H | Murray State | 10 | W | 73 | 10 | 1-0 | 42,185 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 09/06/2007 | H | Middle Tennessee | 8 | W | 58 | 42 | 2-0 | 40,882 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 09/15/2007 | A | Kentucky | 9 | L | 34 | 40 | 2-1 | 70,857 | Lexington | Ky. | Commonwealth Stadium | ||||
| 09/22/2007 | H | Syracuse | 18 | L | 35 | 38 | 2-2 | 0-1 | 40,922 | Louisville | Ky. | Papa John's Cardinal Stadium | |||
| 09/29/2007 | A | North Carolina State | W | 29 | 10 | 3-2 | 0-1 | 56,487 | Raleigh | N.C. | Carter-Finley Stadium | ||||
| 10/05/2007 | H | Utah | L | 35 | 44 | 3-3 | 0-1 | 40,894 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 10/13/2007 | A | 15 | Cincinnati | W | 28 | 24 | 4-3 | 1-1 | 35,097 | Cincinnati | Ohio | Nippert Stadium | |||
| 10/19/2007 | A | RV | Connecticut | L | 17 | 21 | 4-4 | 1-2 | 40,000 | East Hartford | Conn. | Rentschler Field | |||
| 10/27/2007 | H | Pittsburgh | W | 24 | 17 | 5-4 | 2-2 | 34,792 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 11/08/2007 | A | 6 | West Virginia | L | 31 | 38 | 5-5 | 2-3 | 60,992 | Morgantown | W.Va. | Milan Puskar Stadium | |||
| 11/17/2007 | A | RV | South Florida | L | 17 | 55 | 5-6 | 2-4 | 57,288 | Tampa | Fla. | Raymond James Stadium | |||
| 11/29/2007 | H | Rutgers | W | 41 | 38 | 6-6 | 3-4 | 39,612 | Louisville | Ky. | Papa John's Cardinal Stadium |