13 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/01/2014 | H | RV | Miami, Fla. | RV | W | 31 | 13 | 1-0 | 1-0 | 55,428 | Louisville | Ky. | Papa John's Cardinal Stadium | ||
| 09/06/2014 | H | Murray State | 25 | W | 66 | 21 | 2-0 | 1-0 | 50,179 | Louisville | Ky. | Papa John's Cardinal Stadium | |||
| 09/13/2014 | A | Virginia | 21 | L | 21 | 23 | 2-1 | 1-1 | 34,816 | Charlottesville | Va. | Scott Stadium | |||
| 09/20/2014 | A | Florida International | RV | W | 34 | 3 | 3-1 | 1-1 | 10,826 | Miami | Fla. | FIU Stadium | |||
| 09/27/2014 | H | Wake Forest | W | 20 | 10 | 4-1 | 2-1 | 51,463 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 10/03/2014 | A | Syracuse | RV | W | 28 | 6 | 5-1 | 3-1 | 37,569 | Syracuse | N.Y. | Carrier Dome | |||
| 10/11/2014 | A | RV | Clemson | RV | L | 17 | 23 | 5-2 | 3-2 | 81,500 | Clemson | S.C. | Memorial Stadium | ||
| 10/18/2014 | H | North Carolina State | RV | W | 30 | 18 | 6-2 | 4-2 | 50,227 | Louisville | Ky. | Papa John's Cardinal Stadium | |||
| 10/30/2014 | H | 2 | Florida State | RV | L | 31 | 42 | 6-3 | 4-3 | 55,414 | Louisville | Ky. | Papa John's Cardinal Stadium | ||
| 11/08/2014 | A | Boston College | RV | W | 38 | 19 | 7-3 | 5-3 | 33,565 | Chestnut Hill | Mass. | Alumni Stadium | |||
| 11/22/2014 | A | RV | Notre Dame | RV | W | 31 | 28 | 8-3 | 5-3 | 80,795 | South Bend | Ind. | Notre Dame Stadium | ||
| 11/29/2014 | H | Kentucky | 24 | W | 44 | 40 | 9-3 | 5-3 | 55,118 | Louisville | Ky. | Papa John's Cardinal Stadium | |||
| 12/30/2014 | N | 13 | Georgia | 20 | L | 14 | 37 | 9-4 | 5-3 | 45,671 | Charlotte | N.C. | Bank of America Stadium | Belk Bowl |