13 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/05/2015 | N | 6 | Auburn | RV | L | 24 | 31 | 0-1 | 73,927 | Atlanta | Ga. | Georgia Dome | Chick-fil-A Kickoff Game | ||
| 09/12/2015 | H | Houston | RV | L | 31 | 34 | 0-2 | 50,019 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 09/17/2015 | H | 11 | Clemson | L | 17 | 20 | 0-3 | 0-1 | 55,396 | Louisville | Ky. | Papa John's Cardinal Stadium | |||
| 09/26/2015 | H | Samford | W | 45 | 3 | 1-3 | 0-1 | 50,121 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 10/03/2015 | A | North Carolina State | W | 20 | 13 | 2-3 | 1-1 | 56,417 | Raleigh | N.C. | Carter-Finley Stadium | ||||
| 10/17/2015 | A | 11 | Florida State | L | 21 | 41 | 2-4 | 1-2 | 71,225 | Tallahassee | Fla. | Doak Campbell Stadium | |||
| 10/24/2015 | H | Boston College | W | 17 | 14 | 3-4 | 2-2 | 41,486 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 10/30/2015 | A | Wake Forest | W | 20 | 19 | 4-4 | 3-2 | 24,922 | Winston-Salem | N.C. | BB&T Field | ||||
| 11/07/2015 | H | Syracuse | W | 41 | 17 | 5-4 | 4-2 | 46,158 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 11/14/2015 | H | Virginia | W | 38 | 31 | 6-4 | 5-2 | 51,233 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 11/21/2015 | A | Pittsburgh | L | 34 | 45 | 6-5 | 5-3 | 42,119 | Pittsburgh | Pa. | Heinz Field | ||||
| 11/28/2015 | A | Kentucky | W | 38 | 24 | 7-5 | 5-3 | 62,512 | Lexington | Ky. | Commonwealth Stadium | ||||
| 12/30/2015 | N | Texas A&M | W | 27 | 21 | 8-5 | 5-3 | 50,478 | Nashville | Tenn. | Nissan Stadium | Music City Bowl |