31 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1958-12-02 | H | Georgetown College | L | 78 | 84 | 0-1 | 3,893 | Louisville | KY | Freedom Hall | ||||
| 1958-12-06 | H | Georgia Tech | W | 71 | 57 | 1-1 | 5,015 | Louisville | KY | Freedom Hall | ||||
| 1958-12-08 | A | Bradley | L | 48 | 78 | 1-2 | 7,500 | Peoria | IL | |||||
| 1958-12-11 | H | Stetson | W | 81 | 47 | 2-2 | 2,685 | Louisville | KY | Freedom Hall | ||||
| 1958-12-13 | H | Alabama | W | 62 | 43 | 3-2 | 3,000 | Louisville | KY | Freedom Hall | ||||
| 1958-12-17 | H | Wittenberg | W | 56 | 49 | 4-2 | 2,674 | Louisville | KY | Freedom Hall | ||||
| 1958-12-19 | H | 6 | Northwestern | L | 68 | 73 | 4-3 | 6,000 | Louisville | KY | Freedom Hall | 1958 Bluegrass Invitational | ||
| 1958-12-20 | H | Notre Dame | L | 53 | 61 | 4-4 | 6,000 | Louisville | KY | Freedom Hall | 1958 Bluegrass Invitational | |||
| 1958-12-29 | A | 5 | North Carolina State | L | 61 | 67 | 4-5 | 12,000 | Raleigh | NC | 1958 Dixie Classic | |||
| 1958-12-30 | N | Wake Forest | W | 74 | 64 | 5-5 | 12,000 | Raleigh | NC | 1958 Dixie Classic | ||||
| 1958-12-31 | N | Duke | L | 54 | 57 | 5-6 | 12,000 | Raleigh | NC | 1958 Dixie Classic | ||||
| 1959-01-03 | A | Xavier | L | 66 | 98 | 5-7 | 4,750 | Cincinnati | OH | Cincinnati Gardens | ||||
| 1959-01-07 | H | Eastern Kentucky | W | 86 | 75 | 6-7 | 3,309 | Louisville | KY | Freedom Hall | ||||
| 1959-01-10 | H | Xavier | W | 70 | 66 | 7-7 | 5,780 | Louisville | KY | Freedom Hall | ||||
| 1959-01-13 | H | 7 | Bradley | W | 79 | 66 | 8-7 | 4,607 | Louisville | KY | Freedom Hall | |||
| 1959-01-17 | A | 15 | Saint Louis | L | 68 | 69 | 8-8 | 7,000 | St. Louis | MO | ||||
| 1959-01-24 | H | Dayton | W | 76 | 59 | 9-8 | 8,401 | Louisville | KY | Freedom Hall | ||||
| 1959-01-31 | A | 12 | Marquette | 17 | L | 62 | 66 | 9-9 | 11,100 | Milwaukee | WI | Milwaukee Auditorium | ||
| 1959-02-04 | H | Florida Southern | W | 88 | 57 | 10-9 | 2,407 | Louisville | KY | Jefferson County Armory | ||||
| 1959-02-07 | H | Kansas | W | 82 | 74 | 11-9 | 4,000 | Louisville | KY | Freedom Hall | ||||
| 1959-02-10 | H | Tampa | W | 96 | 56 | 12-9 | 2,521 | Louisville | KY | Freedom Hall | ||||
| 1959-02-14 | H | 11 | Marquette | W | 68 | 55 | 13-9 | 8,084 | Louisville | KY | Freedom Hall | |||
| 1959-02-17 | A | DePaul | L | 63 | 70 | 13-10 | 4,000 | Chicago | IL | |||||
| 1959-02-21 | A | Dayton | W | 58 | 54 | 14-10 | 5,750 | Dayton | OH | Dayton Fieldhouse | ||||
| 1959-02-25 | H | DePaul | W | 83 | 66 | 15-10 | 5,202 | Louisville | KY | Freedom Hall | ||||
| 1959-02-28 | H | Ohio | W | 72 | 70 | 16-10 | 3,913 | Louisville | KY | Freedom Hall | ||||
| 1959-03-10 | N | Eastern Kentucky | W | 77 | 63 | 17-10 | 10,500 | Lexington | KY | Memorial Coliseum | 1959 NCAA Tournament First Round | |||
| 1959-03-13 | N | 2 | Kentucky | W | 76 | 61 | 18-10 | 9,200 | Evanston | IL | McGaw Memorial Hall | 1959 NCAA Tournament Mideast Regional Semifinal | ||
| 1959-03-14 | N | 7 | Michigan State | W | 88 | 81 | 19-10 | 9,200 | Evanston | IL | McGaw Memorial Hall | 1959 NCAA Tournament Mideast Regional Final | ||
| 1959-03-20 | H | 10 | West Virginia | L | 79 | 94 | 19-11 | 18,750 | Louisville | KY | Freedom Hall | 1959 NCAA Tournament Semifinal | ||
| 1959-03-21 | H | 5 | Cincinnati | L | 85 | 98 | 19-12 | 18,750 | Louisville | KY | Freedom Hall | 1959 NCAA Tournament Third Place Game |