13 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/02/2017 | N | Purdue | 16 | W | 35 | 28 | 1-0 | 42,647 | Indianapolis | Ind. | Lucas Oil Stadium | Ally Classic | |||
| 09/09/2017 | A | North Carolina | 17 | W | 47 | 35 | 2-0 | 1-0 | 47,000 | Chapel Hill | N.C. | Kenan Stadium | |||
| 09/16/2017 | H | 3 | Clemson | 14 | L | 21 | 47 | 2-1 | 1-1 | 55,588 | Louisville | Ky. | Papa John's Cardinal Stadium | ||
| 09/23/2017 | H | Kent State | 19 | W | 42 | 3 | 3-1 | 1-1 | 47,812 | Louisville | Ky. | Papa John's Cardinal Stadium | |||
| 09/30/2017 | H | Murray State | 17 | W | 55 | 10 | 4-1 | 1-1 | 47,826 | Louisville | Ky. | Papa John's Cardinal Stadium | |||
| 10/05/2017 | A | 24 | North Carolina State | 17 | L | 25 | 39 | 4-2 | 1-2 | 56,107 | Raleigh | N.C. | Carter-Finley Stadium | ||
| 10/14/2017 | H | Boston College | L | 42 | 45 | 4-3 | 1-3 | 44,679 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 10/21/2017 | A | Florida State | W | 31 | 28 | 5-3 | 2-3 | 72,764 | Tallahassee | Fla. | Doak Campbell Stadium | ||||
| 10/28/2017 | A | Wake Forest | L | 32 | 42 | 5-4 | 2-4 | 29,593 | Winston-Salem | N.C. | BB&T Field | ||||
| 11/11/2017 | H | Virginia | W | 38 | 21 | 6-4 | 3-4 | 46,787 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 11/18/2017 | H | Syracuse | W | 56 | 10 | 7-4 | 4-4 | 34,265 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 11/25/2017 | A | Kentucky | W | 44 | 17 | 8-4 | 4-4 | 56,186 | Lexington | Ky. | Kroger Field | ||||
| 12/30/2017 | N | 24 | Mississippi State | L | 27 | 31 | 8-5 | 4-4 | 41,310 | Jacksonville | Fla. | EverBank Field | TaxSlayer Bowl |