14 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/01/2023 | N | Georgia Tech | W | 39 | 34 | 1-0 | 1-0 | 36,101 | Atlanta | Ga. | Mercedes-Benz Stadium | Aflac Kickoff Game | |||
| 09/07/2023 | H | Murray State | W | 56 | 0 | 2-0 | 1-0 | 45,273 | Louisville | Ky. | L&N Federal Credit Union Stadium | ||||
| 09/16/2023 | N | Indiana | W | 21 | 14 | 3-0 | 1-0 | 22,840 | Indianapolis | Ind. | Lucas Oil Stadium | ||||
| 09/23/2023 | H | Boston College | W | 56 | 28 | 4-0 | 2-0 | 48,294 | Louisville | Ky. | L&N Federal Credit Union Stadium | ||||
| 09/29/2023 | A | North Carolina State | W | 13 | 10 | 5-0 | 3-0 | 56,919 | Raleigh | N.C. | Carter-Finley Stadium | ||||
| 10/07/2023 | H | 10 | Notre Dame | 25 | W | 33 | 20 | 6-0 | 3-0 | 59,081 | Louisville | Ky. | L&N Federal Credit Union Stadium | ||
| 10/14/2023 | A | Pittsburgh | 14 | L | 21 | 38 | 6-1 | 3-1 | 46,296 | Pittsburgh | Pa. | Acrisure Stadium | |||
| 10/28/2023 | H | 20 | Duke | 18 | W | 23 | 0 | 7-1 | 4-1 | 52,319 | Louisville | Ky. | L&N Federal Credit Union Stadium | ||
| 11/04/2023 | H | Virginia Tech | 15 | W | 34 | 3 | 8-1 | 5-1 | 49,945 | Louisville | Ky. | L&N Federal Credit Union Stadium | |||
| 11/09/2023 | H | Virginia | 11 | W | 31 | 24 | 9-1 | 6-1 | 44,628 | Louisville | Ky. | L&N Federal Credit Union Stadium | |||
| 11/18/2023 | A | Miami, Fla. | 9 | W | 38 | 31 | 10-1 | 7-1 | 44,996 | Miami | Fla. | Hard Rock Stadium | |||
| 11/25/2023 | H | Kentucky | 9 | L | 31 | 38 | 10-2 | 7-1 | 59,225 | Louisville | Ky. | L&N Federal Credit Union Stadium | |||
| 12/02/2023 | N | 4 | Florida State | 15 | L | 6 | 16 | 10-3 | 7-1 | 62,314 | Charlotte | N.C. | Bank of America Stadium | ACC Championship Game | |
| 12/27/2023 | N | Southern California | 16 | L | 28 | 42 | 10-4 | 7-1 | 35,317 | San Diego | Calif. | Petco Park | Holiday Bowl |