31 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1999-11-19 | A | Virginia Commonwealth | L | 74 | 79 | 0-1 | 0-0 | 7,369 | Richmond | VA | Alltel Pavilion | |||
| 1999-11-25 | N | Xavier | L | 79 | 81 | 0-2 | 0-0 | 8,315 | Anchorage | AK | George M. Sullivan Arena | 1999 Great Alaska Shootout | ||
| 1999-11-26 | N | Georgia | W | 85 | 62 | 1-2 | 0-0 | 7,489 | Anchorage | AK | George M. Sullivan Arena | 1999 Great Alaska Shootout | ||
| 1999-11-27 | A | Alaska-Anchorage | W | 108 | 76 | 2-2 | 0-0 | 7,721 | Anchorage | AK | George M. Sullivan Arena | 1999 Great Alaska Shootout | ||
| 1999-12-04 | H | Louisiana Tech | W | 79 | 67 | 3-2 | 0-0 | 19,112 | Louisville | KY | Freedom Hall | |||
| 1999-12-11 | H | Alabama | W | 87 | 72 | 4-2 | 0-0 | 19,293 | Louisville | KY | Freedom Hall | |||
| 1999-12-15 | H | Central Florida | W | 78 | 58 | 5-2 | 0-0 | 18,469 | Louisville | KY | Freedom Hall | |||
| 1999-12-18 | A | Kentucky | L | 46 | 76 | 5-3 | 0-0 | 23,491 | Lexington | KY | Rupp Arena | |||
| 1999-12-20 | H | Tennessee State | W | 115 | 76 | 6-3 | 0-0 | 17,763 | Louisville | KY | Freedom Hall | |||
| 1999-12-23 | H | 6 | North Carolina | W | 97 | 80 | 7-3 | 0-0 | 19,820 | Louisville | KY | Freedom Hall | ||
| 2000-01-03 | H | Tulane | W | 81 | 70 | 8-3 | 1-0 | 18,213 | Louisville | KY | Freedom Hall | |||
| 2000-01-06 | H | 18 | Utah | W | 75 | 55 | 9-3 | 1-0 | 19,843 | Louisville | KY | Freedom Hall | ||
| 2000-01-08 | H | Southern Mississippi | W | 69 | 67 | 10-3 | 2-0 | 19,346 | Louisville | KY | Freedom Hall | |||
| 2000-01-12 | A | Alabama-Birmingham | 25 | L | 50 | 56 | 10-4 | 2-1 | 6,255 | Birmingham | AL | Bartow Arena | ||
| 2000-01-15 | A | Marquette | 25 | L | 64 | 66 | 10-5 | 2-2 | 12,015 | Milwaukee | WI | Bradley Center | ||
| 2000-01-20 | H | 23 | DePaul | W | 72 | 59 | 11-5 | 3-2 | 19,484 | Louisville | KY | Freedom Hall | ||
| 2000-01-22 | H | Charlotte | L | 59 | 69 | 11-6 | 3-3 | 19,120 | Louisville | KY | Freedom Hall | |||
| 2000-01-27 | H | 1 | Cincinnati | L | 65 | 75 | 11-7 | 3-4 | 19,886 | Louisville | KY | Freedom Hall | ||
| 2000-01-29 | A | Saint Louis | L | 48 | 52 | 11-8 | 3-5 | 13,091 | St. Louis | MO | Kiel Center | |||
| 2000-02-01 | A | Georgetown | L | 59 | 61 | 11-9 | 3-5 | 7,189 | Washington | DC | MCI Center | |||
| 2000-02-05 | A | Memphis | W | 74 | 59 | 12-9 | 4-5 | 15,773 | Memphis | TN | The Pyramid | |||
| 2000-02-10 | H | 4 | Syracuse | W | 82 | 69 | 13-9 | 4-5 | 19,861 | Louisville | KY | Freedom Hall | ||
| 2000-02-13 | H | Marquette | W | 76 | 64 | 14-9 | 5-5 | 19,286 | Louisville | KY | Freedom Hall | |||
| 2000-02-16 | A | Charlotte | W | 67 | 51 | 15-9 | 6-5 | 6,295 | Charlotte | NC | Dale F. Halton Arena | |||
| 2000-02-19 | A | DePaul | W | 71 | 54 | 16-9 | 7-5 | 13,036 | Chicago | IL | United Center | |||
| 2000-02-23 | H | Saint Louis | W | 68 | 56 | 17-9 | 8-5 | 19,022 | Louisville | KY | Freedom Hall | |||
| 2000-02-27 | A | 3 | Cincinnati | L | 59 | 68 | 17-10 | 8-6 | 13,176 | Cincinnati | OH | Shoemaker Center | ||
| 2000-02-29 | H | South Florida | W | 76 | 66 | 18-10 | 9-6 | 19,177 | Louisville | KY | Freedom Hall | |||
| 2000-03-04 | A | Houston | W | 88 | 74 | 19-10 | 10-6 | 4,106 | Houston | TX | Hofheinz Pavilion | |||
| 2000-03-09 | N | Charlotte | L | 52 | 57 | 19-11 | 10-6 | 12,004 | Memphis | TN | The Pyramid | 2000 C-USA Tournament Quarterfinal | ||
| 2000-03-16 | N | Gonzaga | L | 66 | 77 | 19-12 | 10-6 | 13,624 | Tucson | AZ | McKale Center | 2000 NCAA Tournament West Regional First Round |