35 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2024-11-04 | H | Morehead State | W | 93 | 45 | 1-0 | 12,490 | Louisville | KY | KFC Yum! Center | ||||
| 2024-11-09 | H | 12 | Tennessee | L | 55 | 77 | 1-1 | 16,976 | Louisville | KY | KFC Yum! Center | |||
| 2024-11-19 | H | Bellarmine | W | 100 | 68 | 2-1 | 12,220 | Louisville | KY | KFC Yum! Center | ||||
| 2024-11-22 | H | Winthrop | W | 76 | 61 | 3-1 | 12,462 | Louisville | KY | KFC Yum! Center | ||||
| 2024-11-27 | N | 14 | Indiana | W | 89 | 61 | 4-1 | 1,594 | Paradise Island | Bahamas | Atlantis Resort Imperial Arena | 2024 Battle 4 Atlantis First Round | ||
| 2024-11-28 | N | West Virginia | W | 79 | 70 | 5-1 | 767 | Paradise Island | Bahamas | Atlantis Resort Imperial Arena | 2024 Battle 4 Altantis Semifinal | |||
| 2024-11-29 | N | Oklahoma | L | 64 | 69 | 5-2 | 1,866 | Paradise Island | Bahamas | Atlantis Resort Imperial Arena | 2024 Battle 4 Atlantis Championship | |||
| 2024-12-03 | H | 23 | Mississippi | L | 63 | 86 | 5-3 | 12,729 | Louisville | KY | KFC Yum! Center | 2024 SEC-ACC Challenge | ||
| 2024-12-08 | H | 9 | Duke | L | 65 | 76 | 5-4 | 0-1 | 15,312 | Louisville | KY | KFC Yum! Center | ||
| 2024-12-11 | H | Texas-El Paso | W | 77 | 74 | 6-4 | 0-1 | 11,668 | Louisville | KY | KFC Yum! Center | |||
| 2024-12-14 | A | 5 | Kentucky | L | 85 | 93 | 6-5 | 0-1 | 21,093 | Lexington | KY | Rupp Arena | ||
| 2024-12-21 | A | Florida State | W | 90 | 76 | 7-5 | 1-1 | 4,383 | Tallahassee | FL | Donald L. Tucker Civic Center | |||
| 2024-12-28 | H | Eastern Kentucky | W | 78 | 76 | 8-5 | 1-1 | 13,150 | Louisville | KY | KFC Yum! Center | |||
| 2025-01-01 | H | North Carolina | W | 83 | 70 | 9-5 | 2-1 | 14,248 | Louisville | KY | KFC Yum! Center | |||
| 2025-01-04 | A | Virginia | W | 70 | 50 | 10-5 | 3-1 | 13,316 | Charlottesville | VA | John Paul Jones Arena | |||
| 2025-01-07 | H | Clemson | W | 74 | 64 | 11-5 | 4-1 | 14,991 | Louisville | KY | KFC Yum! Center | |||
| 2025-01-11 | A | Pittsburgh | W | 82 | 78 | 12-5 | 5-1 | 9,065 | Pittsburgh | PA | Petersen Events Center | |||
| 2025-01-14 | A | Syracuse | W | 85 | 61 | 13-5 | 6-1 | 19,750 | Syracuse | NY | JMA Wireless Dome | |||
| 2025-01-18 | H | Virginia | W | 81 | 67 | 14-5 | 7-1 | 18,233 | Louisville | KY | KFC Yum! Center | |||
| 2025-01-21 | A | Southern Methodist | 25 | W | 98 | 73 | 15-5 | 8-1 | 6,135 | Dallas | TX | Moody Coliseum | ||
| 2025-01-28 | H | Wake Forest | 21 | W | 72 | 59 | 16-5 | 9-1 | 14,533 | Louisville | KY | KFC Yum! Center | ||
| 2025-02-01 | A | Georgia Tech | 21 | L | 70 | 77 | 16-6 | 9-2 | 6,147 | Atlanta | GA | McCamish Pavilion | ||
| 2025-02-05 | A | Boston College | W | 84 | 58 | 17-6 | 10-2 | 4,204 | Louisville | KY | KFC Yum! Center | |||
| 2025-02-08 | H | Miami, Fla. | W | 88 | 78 | 18-6 | 11-2 | 15,588 | Louisville | KY | KFC Yum! Center | |||
| 2025-02-12 | A | North Carolina State | W | 91 | 66 | 19-6 | 12-2 | 10,029 | Raleigh | NC | Lenovo Arena | |||
| 2025-02-16 | A | Notre Dame | W | 75 | 60 | 20-6 | 13-2 | 5,437 | South Bend | IN | Joyce Athletic and Convocation Center | |||
| 2025-02-22 | H | Florida State | 25 | W | 89 | 81 | 21-6 | 14-2 | 16,473 | Louisville | KY | KFC Yum! Center | ||
| 2025-02-25 | A | Virginia Tech | 19 | W | 71 | 66 | 22-6 | 15-2 | 8,925 | Blacksburg | VA | Cassell Coliseum | ||
| 2025-03-01 | H | Pittsburgh | 19 | W | 79 | 68 | 23-6 | 16-2 | 18,459 | Louisville | KY | KFC Yum! Center | ||
| 2025-03-05 | H | California | 14 | W | 85 | 68 | 24-6 | 17-2 | 14,442 | Louisville | KY | KFC Yum! Center | ||
| 2025-03-08 | H | Stanford | 14 | W | 68 | 48 | 25-6 | 18-2 | 18,707 | Louisville | KY | KFC Yum! Center | ||
| 2025-03-13 | N | Stanford | 13 | W | 75 | 73 | 26-6 | 18-2 | 10,627 | Charlotte | NC | Spectrum Center | 2025 ACC Men's Basketball Tournament Quarterfinals | |
| 2025-03-14 | N | 10 | Clemson | 13 | W | 76 | 73 | 27-6 | 18-2 | 18,116 | Charlotte | NC | Spectrum Center | 2025 ACC Men's Basketball Tournament Semifinals |
| 2025-03-15 | N | 1 | Duke | 13 | L | 62 | 73 | 27-7 | 18-2 | 15,322 | Charlotte | NC | Spectrum Center | 2025 ACC Men's Basketball Tournament Championship |
| 2025-03-20 | N | Creighton | 10 | L | 75 | 89 | 27-8 | 18-2 | 18,769 | Lexington | KY | Rupp Arena | 2025 NCAA Tournament First Round |