30 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2003-11-29 | N | Iowa | 17 | L | 69 | 70 | 0-1 | 0-0 | 19,213 | Indianapolis | IN | Conseco Fieldhouse | 2003 John Wooden Tradition | |
| 2003-12-04 | N | Western Kentucky | W | 93 | 63 | 1-1 | 0-0 | 12,120 | Nashville | TN | Gaylord Entertainment Center | |||
| 2003-12-07 | H | Holy Cross | W | 56 | 40 | 2-1 | 0-0 | 19,232 | Louisville | KY | Freedom Hall | |||
| 2003-12-10 | H | Seton Hall | W | 80 | 71 | 3-1 | 0-0 | 19,328 | Louisville | KY | Freedom Hall | |||
| 2003-12-13 | H | 1 | Florida | W | 73 | 65 | 4-1 | 0-0 | 20,032 | Louisville | KY | Freedom Hall | 2003 Billy Minardi Classic | |
| 2003-12-20 | H | Austin Peay | 20 | W | 80 | 63 | 5-1 | 0-0 | 19,138 | Louisville | KY | Freedom Hall | ||
| 2003-12-23 | H | VMI | 20 | W | 107 | 56 | 6-1 | 0-0 | 18,174 | Louisville | KY | Freedom Hall | ||
| 2003-12-27 | A | 2 | Kentucky | 20 | W | 65 | 56 | 7-1 | 0-0 | 24,328 | Lexington | KY | Rupp Arena | |
| 2003-12-30 | H | Toledo | 11 | W | 92 | 56 | 8-1 | 0-0 | 19,427 | Louisville | KY | Freedom Hall | ||
| 2004-01-03 | H | Murray State | 11 | W | 91 | 69 | 9-1 | 0-0 | 19,292 | Louisville | KY | Freedom Hall | ||
| 2004-01-07 | H | Southern Mississippi | 10 | W | 76 | 42 | 10-1 | 1-0 | 19,319 | Louisville | KY | Freedom Hall | ||
| 2004-01-10 | A | South Florida | 10 | W | 85 | 40 | 11-1 | 2-0 | 7,011 | Tampa | FL | USF Sun Dome | ||
| 2004-01-15 | A | East Carolina | 8 | W | 76 | 66 | 12-1 | 3-0 | 7,553 | Greenville | NC | Williams Arena at Minges Coliseum | ||
| 2004-01-17 | H | Tulane | 8 | W | 79 | 58 | 13-1 | 4-0 | 19,480 | Louisville | KY | Freedom Hall | ||
| 2004-01-21 | H | 6 | Cincinnati | 5 | W | 93 | 66 | 14-1 | 5-0 | 20,079 | Louisville | KY | Freedom Hall | |
| 2004-01-25 | A | Tennessee | 5 | W | 65 | 62 | 15-1 | 5-0 | 15,086 | Knoxville | TN | Thompson-Boling Arena | ||
| 2004-01-28 | H | Houston | 4 | W | 64 | 48 | 16-1 | 6-0 | 19,226 | Louisville | KY | Freedom Hall | ||
| 2004-01-31 | H | Marquette | 4 | L | 70 | 77 | 16-2 | 6-1 | 19,864 | Louisville | KY | Freedom Hall | ||
| 2004-02-04 | A | Memphis | 6 | L | 58 | 62 | 16-3 | 6-2 | 19,044 | Memphis | TN | The Pyramid | ||
| 2004-02-07 | H | Alabama-Birmingham | 6 | W | 73 | 55 | 17-3 | 7-2 | 19,723 | Louisville | KY | Freedom Hall | ||
| 2004-02-12 | A | Charlotte | 9 | L | 71 | 77 | 17-4 | 7-3 | 9,105 | Charlotte | NC | Dale F. Halton Arena | ||
| 2004-02-17 | A | Texas Christian | 10 | L | 46 | 71 | 17-5 | 7-4 | 6,028 | Ft. Worth | TX | Daniel-Meyer Coliseum | ||
| 2004-02-21 | A | 17 | Cincinnati | 10 | L | 61 | 66 | 17-6 | 7-5 | 13,176 | Cincinnati | OH | Fifth Third Arena | |
| 2004-02-25 | H | DePaul | 21 | L | 58 | 60 | 17-7 | 7-6 | 19,505 | Louisville | KY | Freedom Hall | ||
| 2004-02-28 | H | 19 | Memphis | 21 | W | 66 | 60 | 18-7 | 8-6 | 19,824 | Louisville | KY | Freedom Hall | |
| 2004-03-03 | A | Saint Louis | 25 | W | 75 | 48 | 19-7 | 9-6 | 11,020 | St. Louis | MO | Savvis Center | ||
| 2004-03-06 | A | Marquette | 25 | L | 80 | 81 | 19-8 | 9-7 | 17,508 | Milwaukee | WI | Bradley Center | ||
| 2004-03-10 | N | East Carolina | W | 61 | 54 | 20-8 | 9-7 | 13,877 | Cincinnati | OH | U.S. Bank Arena | 2004 C-USA Tournament First Round | ||
| 2004-03-11 | N | 13 | Cincinnati | L | 62 | 64 | 20-9 | 9-7 | 16,202 | Cincinnati | OH | U.S. Bank Arena | 2004 C-USA Tournament Quarterfinal | |
| 2004-03-19 | N | Xavier | L | 70 | 80 | 20-10 | 9-7 | 15,961 | Orlando | FL | TD Waterhouse Centre | 2004 NCAA Tournament Atlanta Regional First Round |