32 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2023-11-06 | H | UMBC | W | 94 | 93 | 1-0 | 11,010 | Louisville | KY | KFC Yum! Center | ||||
| 2023-11-10 | H | Chattanooga | L | 71 | 81 | 1-1 | 10,634 | Louisville | KY | KFC Yum! Center | ||||
| 2023-11-15 | H | Coppin State | W | 61 | 41 | 2-1 | 10,501 | Louisville | KY | KFC Yum! Center | ||||
| 2023-11-19 | N | 19 | Texas | L | 80 | 81 | 2-2 | 19,147 | New York | NY | Madison Square Garden IV | 2023 Empire Classic | ||
| 2023-11-20 | N | Indiana | L | 66 | 74 | 2-3 | 10,988 | New York | NY | Madison Square Garden IV | 2023 Empire Classic | |||
| 2023-11-26 | H | New Mexico State | W | 90 | 84 | 3-3 | 10,527 | Louisville | KY | KFC Yum! Center | ||||
| 2023-11-29 | H | Bellarmine | W | 73 | 68 | 4-3 | 11,538 | Louisville | KY | KFC Yum! Center | ||||
| 2023-12-03 | A | Virginia Tech | L | 68 | 75 | 4-4 | 0-1 | 8,925 | Blacksburg | VA | Cassell Coliseum | |||
| 2023-12-09 | A | DePaul | L | 68 | 75 | 4-5 | 0-1 | 4,255 | Chicago | IL | Wintrust Arena | |||
| 2023-12-13 | H | Arkansas State | L | 63 | 75 | 4-6 | 0-1 | 10,401 | Louisville | KY | KFC Yum! Center | |||
| 2023-12-17 | H | Pepperdine | W | 85 | 63 | 5-6 | 0-1 | 10,475 | Louisville | KY | KFC Yum! Center | |||
| 2023-12-21 | H | 9 | Kentucky | L | 76 | 95 | 5-7 | 0-1 | 17,293 | Louisville | KY | KFC Yum! Center | ||
| 2024-01-03 | A | Virginia | L | 53 | 77 | 5-8 | 0-2 | 13,703 | Charlottesville | VA | John Paul Jones Arena | |||
| 2024-01-06 | H | Pittsburgh | L | 70 | 83 | 5-9 | 0-3 | 10,883 | Louisville | KY | KFC Yum! Center | |||
| 2024-01-10 | A | Miami, Fla. | W | 80 | 71 | 6-9 | 1-3 | 6,929 | Coral Gables | FL | Watsco Center | |||
| 2024-01-13 | H | North Carolina State | L | 83 | 89 | 6-10 | 1-4 | 12,114 | Louisville | KY | KFC Yum! Center | |||
| 2024-01-17 | A | 4 | North Carolina | L | 70 | 86 | 6-11 | 1-5 | 20,298 | Chapel Hill | NC | Dean E. Smith Center | ||
| 2024-01-20 | A | Wake Forest | L | 65 | 90 | 6-12 | 1-6 | 9,261 | Winston-Salem | NC | Lawrence Joel Veterans Memorial Coliseum | |||
| 2024-01-23 | H | 12 | Duke | L | 69 | 83 | 6-13 | 1-7 | 12,620 | Louisville | KY | KFC Yum! Center | ||
| 2024-01-27 | H | Virginia | L | 52 | 69 | 6-14 | 1-8 | 11,381 | Louisville | KY | KFC Yum! Center | |||
| 2024-01-30 | A | Clemson | L | 64 | 70 | 6-15 | 1-9 | 6,760 | Clemson | SC | Littlejohn Coliseum | |||
| 2024-02-03 | H | Florida State | W | 101 | 92 | 7-15 | 2-9 | 11,287 | Louisville | KY | KFC Yum! Center | |||
| 2024-02-07 | A | Syracuse | L | 92 | 94 | 7-16 | 2-10 | 19,426 | Syracuse | NY | JMA Wireless Dome | |||
| 2024-02-10 | H | Georgia Tech | W | 79 | 67 | 8-16 | 3-10 | 11,891 | Louisville | KY | KFC Yum! Center | |||
| 2024-02-13 | A | Boston College | L | 77 | 89 | 8-17 | 3-11 | 3,459 | Chestnut Hill | MA | Conte Forum | |||
| 2024-02-17 | A | Pittsburgh | L | 59 | 86 | 8-18 | 3-12 | 11,419 | Pittsburgh | PA | Petersen Events Center | |||
| 2024-02-21 | H | Notre Dame | L | 50 | 72 | 8-19 | 3-13 | 11,342 | Louisville | KY | KFC Yum! Center | |||
| 2024-02-28 | A | 10 | Duke | L | 59 | 84 | 8-20 | 3-14 | 9,314 | Durham | NC | Cameron Indoor Stadium | ||
| 2024-03-02 | H | Syracuse | L | 76 | 82 | 8-21 | 3-15 | 11,011 | Louisville | KY | KFC Yum! Center | |||
| 2024-03-05 | H | Virginia Tech | L | 64 | 80 | 8-22 | 3-16 | 10,544 | Louisville | KY | KFC Yum! Center | |||
| 2024-03-09 | H | Boston College | L | 61 | 67 | 8-23 | 3-17 | 11,615 | Louisville | KY | KFC Yum! Center | |||
| 2024-03-12 | N | North Carolina State | L | 85 | 94 | 8-24 | 3-17 | 7,523 | Washington | DC | Capital One Arena | 2024 ACC Men's Basketball Tournament First Round |