35 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1987-12-05 | N | Notre Dame | 14 | L | 54 | 69 | 0-1 | 0-0 | 43,601 | Indianapolis | IN | Hoosier Dome | 1987 Bank One Big Four Classic | |
| 1987-12-12 | A | 1 | Kentucky | L | 75 | 76 | 0-2 | 0-0 | 23,489 | Lexington | KY | Rupp Arena | ||
| 1987-12-16 | H | Cleveland State | W | 93 | 79 | 1-2 | 0-0 | 19,281 | Louisville | KY | Freedom Hall | |||
| 1987-12-19 | H | 5 | Indiana | W | 81 | 69 | 2-2 | 0-0 | 19,453 | Louisville | KY | Freedom Hall | ||
| 1987-12-22 | H | Eastern Kentucky | W | 87 | 69 | 3-2 | 0-0 | 19,294 | Louisville | KY | Freedom Hall | |||
| 1987-12-28 | N | Southern Methodist | 20 | W | 87 | 79 | 4-2 | 0-0 | 3,099 | Honolulu | HI | Neal S. Blaisdell Arena | 1987 Rainbow Classic First Round | |
| 1987-12-29 | N | North Carolina State | 20 | L | 75 | 80 | 4-3 | 0-0 | 3,025 | Honolulu | HI | Neal S. Blaisdell Arena | 1987 Rainbow Classic Semifinal | |
| 1987-12-30 | N | Mississippi State | 20 | W | 86 | 62 | 5-3 | 0-0 | 3,000 | Honolulu | HI | Neal S. Blaisdell Arena | 1987 Rainbow Classic Third Place Game | |
| 1988-01-04 | H | South Alabama | W | 80 | 69 | 6-3 | 0-0 | 19,134 | Louisville | KY | Freedom Hall | |||
| 1988-01-06 | H | Georgia Tech | L | 61 | 62 | 0-0 | 19,271 | Louisville | KY | Freedom Hall | ||||
| 1988-01-09 | A | Florida State | L | 76 | 83 | 6-5 | 0-1 | 12,898 | Tallahassee | FL | Tallahassee-Leon County Civic Center | |||
| 1988-01-16 | H | UCLA | W | 92 | 79 | 7-5 | 0-1 | 19,253 | Louisville | KY | Freedom Hall | |||
| 1988-01-18 | H | Western Kentucky | W | 84 | 71 | 8-5 | 0-1 | 19,056 | Louisville | KY | Freedom Hall | |||
| 1988-01-20 | A | Cincinnati | W | 91 | 89 | 9-5 | 1-1 | 9,920 | Cincinnati | OH | Cincinnati Gardens | |||
| 1988-01-23 | H | 5 | Purdue | L | 85 | 91 | 9-6 | 1-1 | 19,553 | Louisville | KY | Freedom Hall | ||
| 1988-01-26 | A | Dayton | W | 90 | 59 | 10-6 | 1-1 | 13,261 | Dayton | OH | University of Dayton Arena | |||
| 1988-01-28 | A | 20 | Southern Mississippi | L | 92 | 95 | 10-7 | 1-2 | 8,095 | Hattiesburg | MS | Reed Green Coliseum | ||
| 1988-01-30 | A | Memphis | L | 68 | 72 | 10-8 | 1-3 | 11,200 | Memphis | TN | Mid-South Coliseum | |||
| 1988-02-01 | H | Virginia Tech | W | 107 | 99 | 11-8 | 2-3 | 19,401 | Louisville | KY | Freedom Hall | |||
| 1988-02-03 | H | South Carolina | W | 68 | 53 | 12-8 | 3-3 | 19,424 | Louisville | KY | Freedom Hall | |||
| 1988-02-06 | H | Houston | W | 73 | 69 | 13-8 | 3-3 | 19,461 | Louisville | KY | Freedom Hall | |||
| 1988-02-13 | A | North Carolina State | L | 89 | 101 | 13-9 | 3-3 | 12,400 | Raleigh | NC | Reynolds Coliseum | |||
| 1988-02-15 | H | Cincinnati | W | 90 | 78 | 14-9 | 4-3 | 19,212 | Louisville | KY | Freedom Hall | |||
| 1988-02-17 | H | Florida State | W | 82 | 62 | 15-9 | 5-3 | 19,286 | Louisville | KY | Freedom Hall | |||
| 1988-02-20 | A | South Carolina | W | 98 | 88 | 16-9 | 6-3 | 10,139 | Columbia | SC | Carolina Coliseum | |||
| 1988-02-24 | H | 18 | Southern Mississippi | W | 94 | 84 | 17-9 | 7-3 | 19,360 | Louisville | KY | Freedom Hall | ||
| 1988-02-27 | A | Virginia Tech | W | 87 | 82 | 18-9 | 8-3 | 10,000 | Blacksburg | VA | Cassell Coliseum | |||
| 1988-02-29 | H | Memphis | W | 71 | 69 | 19-9 | 9-3 | 19,313 | Louisville | KY | Freedom Hall | |||
| 1988-03-02 | H | Austin Peay | W | 84 | 78 | 20-9 | 9-3 | 19,396 | Louisville | KY | Freedom Hall | |||
| 1988-03-05 | A | DePaul | L | 58 | 77 | 20-10 | 9-3 | 17,365 | Rosemont | IL | Rosemont Horizon | |||
| 1988-03-12 | N | South Carolina | W | 89 | 57 | 21-10 | 9-3 | 11,200 | Memphis | TN | Mid-South Coliseum | 1988 Metro Tournament Semifinal | ||
| 1988-03-13 | A | Memphis | W | 81 | 73 | 22-10 | 9-3 | 11,200 | Memphis | TN | Mid-South Coliseum | 1988 Metro Tournament Final | ||
| 1988-03-17 | N | Oregon State | W | 70 | 61 | 23-10 | 9-3 | 10,566 | Atlanta | GA | The Omni | 1988 NCAA Tournament Southeast Regional First Round | ||
| 1988-03-19 | N | 19 | Brigham Young | W | 97 | 76 | 24-10 | 9-3 | 14,528 | Atlanta | GA | The Omni | 1988 NCAA Tournament Southeast Regional Second Round | |
| 1988-03-24 | N | 4 | Oklahoma | L | 98 | 108 | 24-11 | 9-3 | 16,816 | Birmingham | AL | BJCC Coliseum | 1988 NCAA Tournament Southeast Regional Semifinal |