38 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2004-11-20 | A | BYU Hawaii | 14 | W | 89 | 79 | 1-0 | 0-0 | 1,500 | Laie | HI | Cannon Activities Center | ||
| 2004-11-22 | N | Iowa | 12 | L | 71 | 76 | 1-1 | 0-0 | 2,500 | Lahaina | HI | Lahaina Civic Center | 2004 EA Sports Maui Invitational | |
| 2004-11-23 | N | Chaminade | 12 | W | 93 | 63 | 2-1 | 0-0 | 2,500 | Lahaina | HI | Lahaina Civic Center | 2004 EA Sports Maui Invitational | |
| 2004-11-24 | N | Stanford | 12 | W | 82 | 67 | 3-1 | 0-0 | 2,500 | Lahaina | HI | Lahaina Civic Center | 2004 EA Sports Maui Invitational | |
| 2004-12-04 | H | Lafayette | 17 | W | 98 | 57 | 4-1 | 0-0 | 18,398 | Louisville | KY | Freedom Hall | ||
| 2004-12-11 | A | Florida | 13 | W | 74 | 70 | 5-1 | 0-0 | 11,017 | Gainesville | FL | O'Connell Center | ||
| 2004-12-14 | H | North Carolina A&T | 13 | W | 85 | 51 | 6-1 | 0-0 | 18,735 | Louisville | KY | Freedom Hall | ||
| 2004-12-18 | H | 9 | Kentucky | 13 | L | 58 | 60 | 6-2 | 0-0 | 20,088 | Louisville | KY | Freedom Hall | |
| 2004-12-21 | H | IUPUI | 18 | W | 80 | 60 | 7-2 | 0-0 | 19,052 | Louisville | KY | Freedom Hall | 2004 Billy Minardi Classic | |
| 2004-12-22 | H | Austin Peay | 18 | W | 77 | 49 | 8-2 | 0-0 | 8,325 | Louisville | KY | Freedom Hall | 2004 Billy Minardi Classic | |
| 2004-12-27 | H | Morehead State | 19 | W | 104 | 40 | 9-2 | 0-0 | 18,132 | Louisville | KY | Freedom Hall | ||
| 2004-12-30 | H | Eastern Kentucky | 19 | W | 78 | 63 | 10-2 | 0-0 | 19,147 | Louisville | KY | Freedom Hall | ||
| 2005-01-02 | H | Tennessee State | 19 | W | 98 | 64 | 11-2 | 0-0 | 18,561 | Louisville | KY | Freedom Hall | ||
| 2005-01-05 | A | Houston | 17 | L | 67 | 70 | 11-3 | 0-1 | 4,328 | Houston | TX | Hofheinz Pavilion | ||
| 2005-01-08 | H | Texas Christian | 17 | W | 86 | 61 | 12-3 | 1-1 | 19,583 | Louisville | KY | Freedom Hall | ||
| 2005-01-11 | A | Southern Mississippi | 19 | W | 107 | 62 | 13-3 | 2-1 | 6,803 | Hattiesburg | MS | Reed Green Coliseum | ||
| 2005-01-15 | A | 18 | Cincinnati | 19 | W | 69 | 66 | 14-3 | 3-1 | 13,176 | Cincinnati | OH | Fifth Third Arena | |
| 2005-01-19 | H | East Carolina | 14 | W | 92 | 41 | 15-3 | 4-1 | 19,462 | Louisville | KY | Freedom Hall | ||
| 2005-01-22 | H | Tennessee | 14 | W | 85 | 62 | 16-3 | 4-1 | 19,926 | Louisville | KY | Freedom Hall | ||
| 2005-01-26 | H | Marquette | 12 | W | 99 | 52 | 17-3 | 5-1 | 19,717 | Louisville | KY | Freedom Hall | ||
| 2005-01-29 | A | Tulane | 12 | W | 105 | 69 | 18-3 | 6-1 | 3,123 | New Orleans | LA | Fogelman Arena | ||
| 2005-02-02 | H | 18 | Cincinnati | 9 | W | 77 | 70 | 19-3 | 7-1 | 20,064 | Louisville | KY | Freedom Hall | |
| 2005-02-05 | A | Alabama-Birmingham | 9 | W | 77 | 73 | 20-3 | 8-1 | 9,354 | Birmingham | AL | Bartow Arena | ||
| 2005-02-09 | H | Memphis | 9 | L | 68 | 85 | 20-4 | 8-2 | 19,818 | Louisville | KY | Freedom Hall | ||
| 2005-02-12 | H | South Florida | 9 | W | 65 | 57 | 21-4 | 9-2 | 19,829 | Louisville | KY | Freedom Hall | ||
| 2005-02-17 | A | Marquette | 12 | W | 64 | 61 | 22-4 | 10-2 | 15,817 | Milwaukee | WI | Bradley Center | ||
| 2005-02-20 | H | Saint Louis | 12 | W | 84 | 66 | 23-4 | 11-2 | 19,783 | Louisville | KY | Freedom Hall | ||
| 2005-02-26 | A | Memphis | 11 | W | 53 | 44 | 24-4 | 12-2 | 18,000 | Memphis | TN | FedEx Forum | ||
| 2005-03-03 | H | 18 | Charlotte | 9 | W | 94 | 82 | 25-4 | 13-2 | 20,068 | Louisville | KY | Freedom Hall | |
| 2005-03-05 | A | DePaul | 9 | W | 66 | 62 | 26-4 | 14-2 | 16,381 | Rosemont | IL | Allstate Arena | ||
| 2005-03-10 | N | Texas Christian | 6 | W | 85 | 61 | 27-4 | 14-2 | 8,592 | Memphis | TN | FedEx Forum | 2005 C-USA Tournament Quarterfinal | |
| 2005-03-11 | N | Alabama-Birmingham | 6 | W | 74 | 67 | 28-4 | 14-2 | 10,080 | Memphis | TN | FedEx Forum | 2005 C-USA Tournament Semifinal | |
| 2005-03-12 | A | Memphis | 6 | W | 75 | 74 | 29-4 | 14-2 | 10,576 | Memphis | TN | FedEx Forum | 2005 C-USA Tournament Final | |
| 2005-03-18 | N | Louisiana-Lafayette | 4 | W | 68 | 62 | 30-4 | 14-2 | 17,286 | Nashville | TN | Gaylord Entertainment Center | 2005 NCAA Tournament Albuquerque Regional First Round | |
| 2005-03-20 | N | 25 | Georgia Tech | 4 | W | 76 | 54 | 31-4 | 14-2 | 17,286 | Nashville | TN | Gaylord Entertainment Center | 2005 NCAA Tournament Albuquerque Regional Second Round |
| 2005-03-24 | N | 8 | Washington | 4 | W | 93 | 79 | 32-4 | 14-2 | 15,792 | Albuquerque | NM | University Arena | 2005 NCAA Tournament Albuquerque Regional Semifinal |
| 2005-03-26 | N | West Virginia | 4 | W | 93 | 85 | 33-4 | 14-2 | 15,896 | Albuquerque | NM | University Arena | 2005 NCAA Tournament Albuquerque Regional Final | |
| 2005-04-02 | N | 1 | Illinois | 4 | L | 57 | 72 | 33-5 | 14-2 | 47,754 | St. Louis | MO | Edward Jones Dome | 2005 NCAA Tournament Semifinal |