35 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | Overall | Conf | Attendance | City | State | Arena | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2025-11-03 | H | South Carolina State | 11 | W | 104 | 45 | 1-0 | 14,218 | Louisville | KY | KFC Yum! Center | |||
| 2025-11-06 | H | Jackson State | 11 | W | 106 | 70 | 2-0 | 14,412 | Louisville | KY | KFC Yum! Center | |||
| 2025-11-11 | H | 9 | Kentucky | 12 | W | 96 | 88 | 3-0 | 22,586 | Louisville | KY | KFC Yum! Center | ||
| 2025-11-15 | H | Ohio | 12 | W | 106 | 81 | 4-0 | 14,899 | Louisville | KY | KFC Yum! Center | |||
| 2025-11-21 | N | Cincinnati | 6 | W | 74 | 64 | 5-0 | 8,507 | Cincinnati | OH | Heritage Bank Center | The Hoops Classic in Partnership with Caresource | ||
| 2025-11-24 | H | Eastern Michigan | 6 | W | 87 | 46 | 6-0 | 13,832 | Louisville | KY | KFC Yum! Center | |||
| 2025-11-26 | H | NJIT | 6 | W | 104 | 47 | 7-0 | 13,825 | Louisville | KY | KFC Yum! Center | |||
| 2025-12-03 | A | 25 | Arkansas | 6 | L | 80 | 89 | 7-1 | 19,600 | Fayetteville | AR | Bud Walton Arean | 2025 ACC-SEC Challenge | |
| 2025-12-06 | N | 22 | Indiana | 6 | W | 87 | 78 | 8-1 | 18,777 | Indianapolis | IN | Gainbridge Fieldhouse | 2025 CareSource Invitational | |
| 2025-12-13 | H | Memphis | 11 | W | 99 | 73 | 9-1 | 16,355 | Louisville | KY | KFC Yum! Center | |||
| 2025-12-16 | A | 20 | Tennessee | 11 | L | 62 | 83 | 9-2 | 21,678 | Knoxville | TN | Thompson-Boling Arena | ||
| 2025-12-20 | H | Montana | 11 | W | 94 | 54 | 10-2 | 14,076 | Louisville | KY | KFC Yum! Center | |||
| 2025-12-30 | A | California | 16 | W | 90 | 70 | 11-2 | 1-0 | 6,012 | Berkeley | CA | Haas Pavilion | ||
| 2026-01-02 | A | Stanford | 16 | L | 76 | 80 | 11-3 | 1-1 | 4,172 | Stanford | CA | Maples Pavilion | ||
| 2026-01-06 | H | 6 | Duke | 20 | L | 73 | 84 | 11-4 | 1-2 | 17,656 | Louisville | KY | KFC Yum! Center | |
| 2026-01-10 | H | Boston College | 20 | W | 75 | 62 | 12-4 | 2-2 | 14,585 | Louisville | KY | KFC Yum! Center | ||
| 2026-01-13 | H | 16 | Virginia | 20 | L | 70 | 79 | 12-5 | 2-3 | 14,697 | Louisville | KY | KFC Yum! Center | |
| 2026-01-17 | A | Pittsburgh | 20 | W | 100 | 59 | 13-5 | 3-3 | 6,070 | Pittsburgh | PA | Petersen Events Center | ||
| 2026-01-24 | H | Virginia Tech | 23 | W | 85 | 71 | 14-5 | 4-3 | 14,907 | Louisville | KY | KFC Yum! Center | ||
| 2026-01-26 | A | 4 | Duke | 20 | L | 52 | 83 | 14-6 | 4-4 | 9,314 | Durham | NC | Cameron Indoor Stadium | |
| 2026-01-31 | H | Southern Methodist | 20 | W | 88 | 74 | 15-6 | 5-4 | 14,847 | Louisville | KY | KFC Yum! Center | ||
| 2026-02-04 | H | Notre Dame | 24 | W | 76 | 65 | 16-6 | 6-4 | 14,787 | Louisville | KY | KFC Yum! Center | ||
| 2026-02-07 | A | Wake Forest | 24 | W | 88 | 80 | 17-6 | 7-4 | 8,874 | Winston-Salem | NC | Lawrence Joel Veterans Memorial Coliseum | ||
| 2026-02-09 | H | North Carolina State | 24 | W | 118 | 77 | 18-6 | 8-4 | 14,389 | Louisville | KY | KFC Yum! Center | ||
| 2026-02-14 | N | Baylor | 24 | W | 82 | 71 | 19-6 | 8-4 | 3,314 | Fort Worth | TX | Dickies Arena | ||
| 2026-02-17 | A | Southern Methodist | 21 | L | 85 | 95 | 19-7 | 8-5 | 6,326 | Dallas | TX | Moody Coliseum | ||
| 2026-02-21 | H | Georgia Tech | 21 | W | 87 | 70 | 20-7 | 9-5 | 16,350 | Louisville | KY | KFC Yum! Center | ||
| 2026-02-23 | A | 18 | North Carolina | 24 | L | 74 | 77 | 20-8 | 9-6 | 20,577 | Chapel Hill | NC | Dean E. Smith Center | |
| 2026-02-28 | A | Clemson | 24 | L | 75 | 80 | 20-9 | 9-7 | 8,084 | Clemson | SC | Littlejohn Coliseum | ||
| 2026-03-03 | H | Syracuse | W | 77 | 62 | 21-9 | 10-7 | 15,306 | Louisville | KY | KFC Yum! Center | |||
| 2026-03-07 | A | 22 | Miami, Fla. | W | 92 | 89 | 22-9 | 11-7 | 7,972 | Coral Gables | FL | Watsco Center | ||
| 2026-03-11 | N | Southern Methodist | 24 | W | 62 | 58 | 23-9 | 11-7 | 8,116 | Charlotte | NC | Spectrum Center | 2026 ACC Men's Basketball Tournament Second Round | |
| 2026-03-12 | N | Miami, Fla. | 24 | L | 73 | 78 | 23-10 | 11-7 | 11,722 | Charlotte | NC | Spectrum Center | 2026 ACC Men's Basketball Tournament Quarterfinals | |
| 2026-03-19 | N | South Florida | 23 | W | 83 | 79 | 24-10 | 11-7 | 17,182 | Buffalo | NY | KeyBank Center | 2026 NCAA Tournament First Round | |
| 2026-03-21 | N | 11 | Michigan State | 23 | L | 69 | 77 | 24-11 | 11-7 | 17,499 | Buffalo | NY | KeyBank Center | 2026 NCAA Tournament Second Round |